التفاصيل البيبلوغرافية
العنوان:
Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
المؤلفون:
James A. Hutchinson , Katharina Kronenberg , Paloma Riquelme , Jürgen J. Wenzel , Gunther Glehr , Hannah-Lou Schilling , Florian Zeman , Katja Evert , Martin Schmiedel , Marion Mickler , Konstantin Drexler , Florian Bitterer , Laura Cordero , Lukas Beyer , Christian Bach , Josef Koestler , Ralph Burkhardt , Hans J. Schlitt , Dirk Hellwig , Jens M. Werner , Rainer Spang , Barbara Schmidt , Edward K. Geissler , Sebastian Haferkamp
المصدر:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
بيانات النشر:
Nature Portfolio, 2021.
سنة النشر:
2021
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Checkpoint blocking therapies are used to treat metastatic melanoma, but can have adverse immune-mediated effects, including liver pathology. Here the authors identify an expanded pool of CD4+ effector memory T cells resulting from prior CMV exposure as a risk factor for this adverse effect in these patients.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
العلاقة:
https://doaj.org/toc/2041-1723Test
DOI:
10.1038/s41467-021-21572-y
الوصول الحر:
https://doaj.org/article/f92b658607e1458c8aa40adb3861c519Test
رقم الانضمام:
edsdoj.f92b658607e1458c8aa40adb3861c519
قاعدة البيانات:
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