التفاصيل البيبلوغرافية
العنوان:
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus
المؤلفون:
Simon H. Jiang , Vicki Athanasopoulos , Julia I. Ellyard , Aaron Chuah , Jean Cappello , Amelia Cook , Savit B. Prabhu , Jacob Cardenas , Jinghua Gu , Maurice Stanley , Jonathan A. Roco , Ilenia Papa , Mehmet Yabas , Giles D. Walters , Gaetan Burgio , Kathryn McKeon , James M. Byers , Charlotte Burrin , Anselm Enders , Lisa A. Miosge , Pablo F. Canete , Marija Jelusic , Velibor Tasic , Adrian C. Lungu , Stephen I. Alexander , Arthur R. Kitching , David A. Fulcher , Nan Shen , Todor Arsov , Paul A. Gatenby , Jeff J. Babon , Dominic F. Mallon , Carmen de Lucas Collantes , Eric A. Stone , Philip Wu , Matthew A. Field , Thomas D. Andrews , Eun Cho , Virginia Pascual , Matthew C. Cook , Carola G. Vinuesa
المصدر:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
بيانات النشر:
Nature Portfolio, 2019.
سنة النشر:
2019
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in the majority of lupus patients and healthy controls, but only the variants found in lupus patients alter gene function.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
العلاقة:
https://doaj.org/toc/2041-1723Test
DOI:
10.1038/s41467-019-10242-9
الوصول الحر:
https://doaj.org/article/78a180011b6f49c096a0159adcd221f4Test
رقم الانضمام:
edsdoj.78a180011b6f49c096a0159adcd221f4
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