Publisher Correction: Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep
| العنوان: | Publisher Correction: Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep |
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| المؤلفون: | Sheng-Yun Wang, Fen-Lan Luo, Si-Yi Wen, Nian Yang, Jiao Cai, Guan-Zhong Wang, Jing Chen, Hao-Yi Li, Hui Feng, Kai-Xuan Zhang, Jun Zhang, Zhian Hu, Yu-Jie Pang, Qi-Cheng Qiao |
| المصدر: | Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020) Nature Communications |
| بيانات النشر: | Nature Portfolio, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Patch-Clamp Techniques, Hypocretin, Science, General Physics and Astronomy, Action Potentials, Sleep, REM, Mice, Transgenic, General Biochemistry, Genetics and Molecular Biology, Rats, Sprague-Dawley, Mice, Orexin Receptors, Medicine, Animals, Humans, Wakefulness, lcsh:Science, Neurons, Orexins, Multidisciplinary, Behavior, Animal, business.industry, Electromyography, Electroencephalography, General Chemistry, Sleep in non-human animals, Publisher Correction, Orexin, Electrodes, Implanted, Rats, Optogenetics, Disease Models, Animal, medicine.anatomical_structure, Muscle Tonus, Sleep Deprivation, lcsh:Q, REM sleep, business, Neuroscience, Nucleus, Brain Stem |
| الوصف: | The relationship between orexin/hypocretin and rapid eye movement (REM) sleep remains elusive. Here, we find that a proportion of orexin neurons project to the sublaterodorsal tegmental nucleus (SLD) and exhibit REM sleep-related activation. In SLD, orexin directly excites orexin receptor-positive neurons (occupying ~3/4 of total-population) and increases gap junction conductance among neurons. Their interaction spreads the orexin-elicited partial-excitation to activate SLD network globally. Besides, the activated SLD network exhibits increased probability of synchronized firings. This synchronized excitation promotes the correspondence between SLD and its downstream target to enhance SLD output. Using optogenetics and fiber-photometry, we consequently find that orexin-enhanced SLD output prolongs REM sleep episodes through consolidating brain state activation/muscle tone inhibition. After chemogenetic silencing of SLD orexin signaling, a ~17% reduction of REM sleep amounts and disruptions of REM sleep muscle atonia are observed. These findings reveal a stabilization role of orexin in REM sleep. |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d0162fbc4ac89d91026193c5bf963dTest https://doaj.org/article/56fccedeee1643478c94bdf7bd880546Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....04d0162fbc4ac89d91026193c5bf963d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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