نتائج البحث

1

Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

المؤلفون: Jie Yang, Shanshan Li, Simeng Zhao, Tong Wang, Min Diao, Cuiping Tian, Zhi-Jie Liu, Fangzhi Tan, Tian Hua, Garth John Thompson, Ying Zhang, Chao-Po Lin, Dylan Deska-Gauthier, Wenqing Shui, Guisheng Zhong, Ya Qin, Hui Li, Quan Wang

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, Fluorescence-lifetime imaging microscopy, Cannabinoid receptor, medicine.drug_class, medicine.medical_treatment, Science, General Physics and Astronomy, Article, General Biochemistry, Genetics and Molecular Biology, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Receptor, Cannabinoid, CB1, medicine, Animals, Super-resolution microscopy, Receptor, lcsh:Science, Cells, Cultured, Cytoskeleton, G protein-coupled receptor, Mice, Knockout, Neurons, Multidisciplinary, Chemistry, musculoskeletal, neural, and ocular physiology, Brain, Fluorescence recovery after photobleaching, food and beverages, General Chemistry, Cellular neuroscience, Axons, Molecular Imaging, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, Microscopy, Fluorescence, nervous system, Female, lcsh:Q, lipids (amino acids, peptides, and proteins), Cannabinoid, psychological phenomena and processes, 030217 neurology & neurosurgery, Intracellular, Fluorescence Recovery After Photobleaching

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb0d5ec2495d751afd669beaea9c4f2Test
https://doaj.org/article/16d642a130464ca1a75800a5fd41828bTest

2

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

المؤلفون: Wen-Wei Qiu, Wang Jie, Fan Yang, Jie Luo, Bao-Liang Song, Wei Qi, Hui Li, Shi-You Jiang, Jie Tang, Jin-Kai Wang, Xiongjie Shi, Jing-Jie Tang, Bing Liu, Hai-Wei Cui

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Male, Statin, medicine.drug_class, Science, General Physics and Astronomy, CHO Cells, Reductase, Pharmacology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Cricetulus, Cell Line, Tumor, medicine, Animals, Humans, lcsh:Science, chemistry.chemical_classification, Multidisciplinary, biology, Molecular Structure, Cholesterol, Ubiquitination, Drug Synergism, General Chemistry, Sterol, Plaque, Atherosclerotic, Ubiquitin ligase, Sterols, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Low-density lipoprotein, HMG-CoA reductase, Proteolysis, biology.protein, Hydroxymethylglutaryl CoA Reductases, lipids (amino acids, peptides, and proteins), lcsh:Q, Hydroxymethylglutaryl-CoA Reductase Inhibitors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda3908f58e97e3451eb6bd260dba8dbTest
http://link.springer.com/article/10.1038/s41467-018-07590-3Test

3

The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

المؤلفون: Ran Yang, Hui Li, Huijie Yang, Yuan Fu, Qi Zhang, Ting Wang, Fang Xianlong, Jinfa Gu, Jianwen Xiao, Xueping Cao, Yeyi Li, Qiujing Yu, Man Shang, Jianju Zhang, Tao Chen, Kangjian Zhang, Xinyuan Liu

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, Carcinogenesis, General Physics and Astronomy, B7-H1 Antigen, Mice, 0302 clinical medicine, Aminohydrolases, RNA, Small Interfering, Regulation of gene expression, Mice, Inbred BALB C, Multidisciplinary, Uridine Diphosphate N-Acetylglucosamine, biology, Effector, Cancer metabolism, Cell biology, Tumor Burden, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Tumour immunology, Signal transduction, Signal Transduction, Cell signalling, Cell signaling, Science, Primary Cell Culture, Mice, Nude, Mechanistic Target of Rapamycin Complex 1, General Biochemistry, Genetics and Molecular Biology, Article, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, Immune system, Folic Acid, Downregulation and upregulation, PD-L1, Cell Line, Tumor, medicine, Animals, Humans, Methylenetetrahydrofolate Dehydrogenase (NADP), Cancer, General Chemistry, Fibroblasts, medicine.disease, Embryo, Mammalian, Multifunctional Enzymes, Xenograft Model Antitumor Assays, Mice, Inbred C57BL, Pancreatic Neoplasms, 030104 developmental biology, biology.protein, Tumor Escape, Protein Processing, Post-Translational, Proto-Oncogene Proteins c-akt, T-Lymphocytes, Cytotoxic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da5d3f5b8a3c1514ed3180cb9e1864eTest
https://pubmed.ncbi.nlm.nih.gov/33782411Test

4

A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma

المؤلفون: Yuemeng Jia, Xinrui Shi, Loryn Facemire, James Mandell, Zhongqiu Xie, Ai Qun Liu, Hui Li, Roger Abounader, Sandeep Singh, Ying Zhang, Paweł Ł. Janczyk, Dorothy A. Schafer, Zi Li, Kristopher E. Kubow

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Science, Blotting, Western, Fluorescent Antibody Technique, General Physics and Astronomy, macromolecular substances, In Vitro Techniques, Biology, Real-Time Polymerase Chain Reaction, medicine.disease_cause, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, Cell Line, Tumor, medicine, Animals, Humans, Gene silencing, lcsh:Science, Cancer genetics, Cytoskeleton, Cell Proliferation, Regulation of gene expression, Mice, Inbred BALB C, Microscopy, Confocal, Multidisciplinary, Oncogene, Brain Neoplasms, Cell growth, Microfilament Proteins, Contact inhibition, Oncogenes, General Chemistry, Immunohistochemistry, Neural stem cell, 030104 developmental biology, Cell culture, 030220 oncology & carcinogenesis, Cancer research, lcsh:Q, Glioblastoma, Carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a369a538336353b26a6f35bc4734ad3Test
https://doi.org/10.1038/s41467-020-17279-1Test

5

In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse

المؤلفون: John M. Shelton, Chengzu Long, Eric N. Olson, Yu Zhang, John R. McAnally, Efrain Sanchez-Ortiz, Yi Li Min, Rhonda Bassel-Duby, Leonela Amoasii, Samadrita Bhattacharyya, Hui Li, Alex A. Mireault

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)

مصطلحات موضوعية: 0301 basic medicine, CRISPR-Cas9 genome editing, Male, Intravital Microscopy, Duchenne muscular dystrophy, General Physics and Astronomy, medicine.disease_cause, Dystrophin, Exon, Mice, 0302 clinical medicine, Genes, Reporter, Muscular dystrophy, lcsh:Science, Luciferases, Gene Editing, Mutation, Multidisciplinary, biology, Genetic disorder, Exons, Neuromuscular disease, Dependovirus, musculoskeletal system, 3. Good health, Cell biology, Treatment Outcome, musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities, Science, Genetic Vectors, Mice, Transgenic, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, medicine, Bioluminescence imaging, Animals, Humans, Luciferase, Muscle, Skeletal, General Chemistry, Genetic Therapy, medicine.disease, Muscular Dystrophy, Duchenne, Disease Models, Animal, 030104 developmental biology, Luminescent Measurements, biology.protein, lcsh:Q, CRISPR-Cas Systems, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f686174230b11caf2610ab2e1d728ed3Test
http://europepmc.org/articles/PMC6778191Test

6

An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration

المؤلفون: Yun Qian, Xiaotian Zhao, Wei Chen, Qixin Han, Hui Li, Weien Yuan

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications

مصطلحات موضوعية: Male, Scaffold, Indoles, Polymers, General Physics and Astronomy, Biocompatible Materials, 02 engineering and technology, 01 natural sciences, Nanomaterials, law.invention, Rats, Sprague-Dawley, chemistry.chemical_compound, Tissue engineering, law, Peripheral Nerve Injuries, Materials Testing, Nanotechnology, lcsh:Science, Multidisciplinary, Tissue Scaffolds, food and beverages, 021001 nanoscience & nanotechnology, Sciatic Nerve, Peripheral nerve injury, Polycaprolactone, Printing, Three-Dimensional, Graphite, 0210 nano-technology, Oligopeptides, Porosity, Materials science, Polyesters, Science, Primary Cell Culture, 010402 general chemistry, General Biochemistry, Genetics and Molecular Biology, Article, Cell Adhesion, Animals, Cell adhesion, Tissue Engineering, Graphene, Electric Conductivity, General Chemistry, 0104 chemical sciences, Nerve Regeneration, Rats, chemistry, lcsh:Q, Schwann Cells, Biomedical engineering, Arginylglycylaspartic acid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370482e8d01e845e674be9c3c51707aeTest
https://doaj.org/article/d82c1622ec93495d9cdb8c9581459c38Test

7

Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop

المؤلفون: Hui Li, Qiang Qin, Yan Zou, Wenlong Lin, Zhiyong Liu, Yuanyuan Zhang, Chunmei Ma, Xiaojian Wang, Yuting Yang, Jihong Sun, Meidi Gu, Feng Ma, Cheng Wu, Jia’nan Shou

المصدر: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

مصطلحات موضوعية: 0301 basic medicine, Male, General Physics and Astronomy, Herpesvirus 1, Human, Mice, Interferon, STAT1, lcsh:Science, Child, Feedback, Physiological, Mice, Knockout, Multidisciplinary, biology, Translation (biology), Cell biology, STAT1 Transcription Factor, Host-Pathogen Interactions, Signal transduction, medicine.drug, Signal Transduction, Science, Protein Serine-Threonine Kinases, General Biochemistry, Genetics and Molecular Biology, Article, Vesicular stomatitis Indiana virus, Proinflammatory cytokine, 03 medical and health sciences, Immune system, medicine, Animals, Bronchiolitis, Viral, Humans, Protein kinase A, Innate immune system, Interferon-alpha, General Chemistry, Interferon-beta, Immunity, Innate, Mice, Inbred C57BL, MicroRNAs, 030104 developmental biology, HEK293 Cells, RAW 264.7 Cells, Gene Expression Regulation, Case-Control Studies, Protein Biosynthesis, Respiratory Syncytial Virus, Human, biology.protein, lcsh:Q

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9b138c7b00cae4a7b161b3685a948aTest
http://europepmc.org/articles/PMC6050289Test

8

Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection

المصدر: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8502d5d215d1dc53d83b39c82ce791dTest
https://doi.org/10.1038/s41467-018-04217-5Test

9

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation

المؤلفون: Xudong Wu, Esben Pedersen, Qi Yao, Paola Lovato, Mette Sidsel Mortensen, Caroline Vinkel, Björn Rozell, Simon Francis Thomsen, Ari Waisman, Lone Veng, Justus Hülse, Cord Brakebusch, Hui Li, Alberto Garcia Mariscal, Salvador Aznar Benitah, Alexandra Avgustinova, Hanne Norsgaard, Kristian Helin

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Nature Communications
Li, H, Yao, Q, Mariscal, A G, Wu, X, Hülse, J, Pedersen, E, Helin, K, Waisman, A, Vinkel, C, Thomsen, S F, Avgustinova, A, Benitah, S A, Lovato, P, Norsgaard, H, Mortensen, M S, Veng, L, Rozell, B & Brakebusch, C 2018, ' Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation ', Nature Communications, vol. 9, no. 1, 1420, pp. 1-18 . https://doi.org/10.1038/s41467-018-03704-zTest

مصطلحات موضوعية: Keratinocytes, Male, 0301 basic medicine, medicine.medical_treatment, Wiskott-Aldrich Syndrome Protein, Neuronal, General Physics and Astronomy, Epigenesis, Genetic, Histones, Mice, 0302 clinical medicine, Genes, Reporter, Interleukin 23, Promoter Regions, Genetic, lcsh:Science, Skin, Mice, Knockout, Multidisciplinary, Interleukin-17, Middle Aged, Cytokine, 030220 oncology & carcinogenesis, Histone methyltransferase, Tumor necrosis factor alpha, Signal transduction, medicine.symptom, Signal Transduction, Adult, Science, Green Fluorescent Proteins, Primary Cell Culture, Inflammation, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Immune system, Psoriasis, medicine, Animals, Humans, Histone-Lysine N-Methyltransferase, General Chemistry, biochemical phenomena, metabolism, and nutrition, medicine.disease, Disease Models, Animal, HEK293 Cells, 030104 developmental biology, Interleukin-23 Subunit p19, Cancer research, lcsh:Q

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9412f73f8cb60dfa9d6a708931e85acTest
https://doi.org/10.1038/s41467-018-03704-zTest

10

Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis

المصدر: Nature Communications

مصطلحات موضوعية: Male, General Physics and Astronomy, NF-KappaB Inhibitor alpha, Missing heritability problem, Exome, Receptors, Interferon, Genetics, education.field_of_study, Multidisciplinary, Interleukin-12 Subunit p40, Microfilament Proteins, Serine Endopeptidases, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, Middle Aged, DNA-Binding Proteins, Female, I-kappa B Proteins, SNP array, Adult, Adolescent, Population, Nerve Tissue Proteins, Receptors, Cell Surface, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Minor Histocompatibility Antigens, Young Adult, Asian People, Cornified Envelope Proline-Rich Proteins, Psoriasis, medicine, Humans, Genetic Predisposition to Disease, education, Methylenetetrahydrofolate Reductase (NADPH2), Genetic association, Membrane Proteins, Correction, General Chemistry, Heritability, medicine.disease, Interleukin-1 Receptor-Like 1 Protein, Adaptor Proteins, Vesicular Transport, Case-Control Studies, Trans-Activators, Receptors, Calcium-Sensing

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c9eaee700d58f1ea8f65e86be7afa5Test
https://doi.org/10.1038/ncomms7793Test

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