التفاصيل البيبلوغرافية
| العنوان: |
Genomic and immune profiling of pre-invasive lung adenocarcinoma. |
| المؤلفون: |
Chen, Haiquan, Carrot-Zhang, Jian, Zhao, Yue, Hu, Haichuan, Freeman, Samuel S., Yu, Su, Ha, Gavin, Taylor, Alison M., Berger, Ashton C., Westlake, Lindsay, Zheng, Yuanting, Zhang, Jiyang, Ramachandran, Aruna, Zheng, Qiang, Pan, Yunjian, Zheng, Difan, Zheng, Shanbo, Cheng, Chao, Kuang, Muyu, Zhou, Xiaoyan |
| المصدر: |
Nature Communications; 11/29/2019, Vol. 10 Issue 1, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
ADENOCARCINOMA, HETEROZYGOSITY, TUMOR immunology, GENOMES, IMMUNE response, TRANSCRIPTOMES |
| مستخلص: |
Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood. Here we report exome and transcriptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenocarcinomas. We have identified EGFR, RBM10, BRAF, ERBB2, TP53, KRAS, MAP2K1 and MET as significantly mutated genes in the pre/minimally invasive group. Classes of genome alterations that increase in frequency during the progression to malignancy are revealed. These include mutations in TP53, arm-level copy number alterations, and HLA loss of heterozygosity. Immune infiltration is correlated with copy number alterations of chromosome arm 6p, suggesting a link between arm-level events and the tumor immune environment. The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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