Re-definition of claudin-low as a breast cancer phenotype
| العنوان: | Re-definition of claudin-low as a breast cancer phenotype |
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| المؤلفون: | Christian Fougner, Therese Sørlie, Helga Bergholtz, Jens Henrik Norum |
| المصدر: | Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020) Nature Communications |
| بيانات النشر: | Nature Portfolio, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Genome instability, Stromal cell, endocrine system diseases, Classification and taxonomy, Science, General Physics and Astronomy, Breast Neoplasms, Biology, urologic and male genital diseases, digestive system, Article, General Biochemistry, Genetics and Molecular Biology, Transcriptome, 03 medical and health sciences, Immune system, Breast cancer, 0302 clinical medicine, Gene expression, Biomarkers, Tumor, medicine, Humans, lcsh:Science, skin and connective tissue diseases, Cancer, Regulation of gene expression, Multidisciplinary, Gene Expression Profiling, Diagnostic markers, General Chemistry, Claudin-Low, medicine.disease, Phenotype, digestive system diseases, Gene Expression Regulation, Neoplastic, Gene expression profiling, 030104 developmental biology, 030220 oncology & carcinogenesis, Claudins, Cancer research, Female, lcsh:Q, tissues |
| الوصف: | The claudin-low breast cancer subtype is defined by gene expression characteristics and encompasses a remarkably diverse range of breast tumors. Here, we investigate genomic, transcriptomic, and clinical features of claudin-low breast tumors. We show that claudin-low is not simply a subtype analogous to the intrinsic subtypes (basal-like, HER2-enriched, luminal A, luminal B and normal-like) as previously portrayed, but is a complex additional phenotype which may permeate breast tumors of various intrinsic subtypes. Claudin-low tumors are distinguished by low genomic instability, mutational burden and proliferation levels, and high levels of immune and stromal cell infiltration. In other aspects, claudin-low tumors reflect characteristics of their intrinsic subtype. Finally, we explore an alternative method for identifying claudin-low tumors and thereby uncover potential weaknesses in the established claudin-low classifier. In sum, these findings elucidate the heterogeneity in claudin-low breast tumors, and substantiate a re-definition of claudin-low as a cancer phenotype. In breast cancer, the claudin-low breast cancer subtype is remarkably diverse. Here, the authors propose that claudin-low is not a classical intrinsic breast cancer subtype, but rather a complex additional phenotype that can occur across intrinsic subtypes. |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90696509b3868e4bc726a927f11d5d96Test https://doaj.org/article/cda6d23debbe4bd5b9bd7b754c0eb7c2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....90696509b3868e4bc726a927f11d5d96 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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