Disentangling the role of Africa in the global spread of H5 highly pathogenic avian influenza
| العنوان: | Disentangling the role of Africa in the global spread of H5 highly pathogenic avian influenza |
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| المؤلفون: | Philippe Lemey, Gianpiero Zamperin, Clement Meseko, Emilie Go-Maro, Abel Wade, Emmanuel Couacy-Hymann, Abdou Alassane, Tony M. Joannis, Isabella Monne, Nicolas Gaidet, Maman Moutari Souley, Bram Vrancken, Adelaide Milani, Alice Fusaro, Yao P. Akpeli, M.’ Bétiégué Coulibaly, Germaine L Minoungou, Lidewij Wiersma, Augustin T. Twabela, Joseph A. Awuni, Bianca Zecchin, Deo Birungi Ndumu, Ismaila Shittu, Abdelsatar Arafa, Rose Ademun, Celia Abolnik, Simon Dickmu Jumbo |
| المصدر: | Nature Communications Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, viruses, animal diseases, MANDARIN DUCK, General Physics and Astronomy, Viral transmission, Joint analysis, medicine.disease_cause, Poultry, West africa, EXPERIMENTAL-INFECTION, MOVEMENT ECOLOGY, Influenza A virus, MULTIPLE INTRODUCTIONS, EPIDEMIOLOGY, Influenza A Virus, H5N8 Subtype, lcsh:Science, Spatial diffusion, Phylogeny, Multidisciplinary, Ecology, food and beverages, virus diseases, Multidisciplinary Sciences, Phylogenetics, Africa, Western, Science & Technology - Other Topics, A H5N8, Viral epidemiology, Highly pathogenic, Science, 030106 microbiology, Biology, complex mixtures, Article, General Biochemistry, Genetics and Molecular Biology, Virus, 03 medical and health sciences, Influenza, Human, medicine, Animals, Humans, Poultry Diseases, A(H5N8) VIRUS, Science & Technology, Influenza A Virus, H5N1 Subtype, General Chemistry, Influenza A virus subtype H5N1, 030104 developmental biology, Influenza in Birds, Africa, WILD BIRDS, lcsh:Q, Influenza virus, GENETIC-CHARACTERIZATION, CLADE 2.3.4.4 |
| الوصف: | The role of Africa in the dynamics of the global spread of a zoonotic and economically-important virus, such as the highly pathogenic avian influenza (HPAI) H5Nx of the Gs/GD lineage, remains unexplored. Here we characterise the spatiotemporal patterns of virus diffusion during three HPAI H5Nx intercontinental epidemic waves and demonstrate that Africa mainly acted as an ecological sink of the HPAI H5Nx viruses. A joint analysis of host dynamics and continuous spatial diffusion indicates that poultry trade as well as wild bird migrations have contributed to the virus spreading into Africa, with West Africa acting as a crucial hotspot for virus introduction and dissemination into the continent. We demonstrate varying paths of avian influenza incursions into Africa as well as virus spread within Africa over time, which reveal that virus expansion is a complex phenomenon, shaped by an intricate interplay between avian host ecology, virus characteristics and environmental variables. The role of Africa in the global spread of highly pathogenic avian influenza (HPAI) is not well understood. Here, using evolutionary analyses, the authors show that Africa mainly acts as ecological sink for HPAI H5, and reveal varying paths of HPAI incursions either through domestic or wild birds. |
| وصف الملف: | text; Electronic |
| تدمد: | 2041-1723 |
| DOI: | 10.1038/s41467-019-13287-y |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae3fe1dc2ad509dcc02a4a3b85ed22dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2ae3fe1dc2ad509dcc02a4a3b85ed22d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-019-13287-y |