Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
| العنوان: | Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport |
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| المؤلفون: | Jimmy F.P. Berbée, M. Lisa Cherradi, Alexander Bartelt, Klaus Toedter, Mariëtte R. Boon, Joerg Heeren, Markus Heine, Sander L. J. Wijers, Clara John, Nicola Schaltenberg, Christian Schlein, F. Rinninger, Wouter D. van Marken Lichtenbelt, Markus Fischer, Anna Worthmann, Julia Piepenburg, Ludger Scheja, Patrick C.N. Rensen, Stefan K. Nilsson, Andreas Niemeier |
| المساهمون: | RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - HB/BW section B, RS: NUTRIM - R1 - Metabolic Syndrome |
| المصدر: | Nature Communications Nature Communications, 8 Nature Communications, 8:15010. Nature Publishing Group Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, CD36 Antigens, Male, General Physics and Astronomy, 030204 cardiovascular system & hematology, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, Brown adipose tissue, Adipocytes, Multidisciplinary, BROWN ADIPOSE-TISSUE, Reverse cholesterol transport, ADAPTIVE THERMOGENESIS, Thermogenesis, Läkemedelskemi, Cold Temperature, medicine.anatomical_structure, Cholesterol, Liver, CARDIOVASCULAR-DISEASE, Metabolome, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL, SCAVENGER RECEPTOR, medicine.medical_specialty, animal structures, Cardiotonic Agents, COLD-EXPOSURE, Science, Lipolysis, TYPE-2 DIABETES-MELLITUS, Hyperlipidemias, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Scavenger receptor, CELLULAR CHOLESTEROL, Triglycerides, APOLIPOPROTEIN-A-I, Cholesterol, HDL, ENERGY-EXPENDITURE, Biological Transport, General Chemistry, Beige Adipocytes, Mice, Inbred C57BL, Lipoprotein Lipase, 030104 developmental biology, Endocrinology, chemistry, Medicinal Chemistry, HIGH-DENSITY-LIPOPROTEIN |
| الوصف: | Brown and beige adipocytes combust nutrients for thermogenesis and through their metabolic activity decrease pro-atherogenic remnant lipoproteins in hyperlipidemic mice. However, whether the activation of thermogenic adipocytes affects the metabolism and anti-atherogenic properties of high-density lipoproteins (HDL) is unknown. Here, we report a reduction in atherosclerosis in response to pharmacological stimulation of thermogenesis linked to increased HDL levels in APOE*3-Leiden.CETP mice. Both cold-induced and pharmacological thermogenic activation enhances HDL remodelling, which is associated with specific lipidomic changes in mouse and human HDL. Furthermore, thermogenic stimulation promotes HDL-cholesterol clearance and increases macrophage-to-faeces reverse cholesterol transport in mice. Mechanistically, we show that intravascular lipolysis by adipocyte lipoprotein lipase and hepatic uptake of HDL by scavenger receptor B-I are the driving forces of HDL-cholesterol disposal in liver. Our findings corroborate the notion that high metabolic activity of thermogenic adipocytes confers atheroprotective properties via increased systemic cholesterol flux through the HDL compartment. Activation of brown adipose tissue (BAT) reduces the development of atherosclerosis in animal models. Here the authors show that BAT activation also increases reverse cholesterol transport and turnover of high-density lipoprotein, which likely contributes to the anti-atherosclerotic effect of BAT activation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7dafcc60f37653488c961c3f64e61fTest https://doi.org/10.1038/ncomms15010Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b7dafcc60f37653488c961c3f64e61f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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