نتائج البحث

1

Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

المؤلفون: Geethani Bandara, Young-Eun Cho, Do-Kyun Kim, Ho Min Kim, Ana Olivera, Moon-Chang Baek, Dean D. Metcalfe, Baktiar Karim, Danielle R. Donahue, Hirsh D. Komarow

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Bone disease, Cellular differentiation, Osteoporosis, General Physics and Astronomy, Core Binding Factor Alpha 1 Subunit, Myeloproliferative disease, Mice, 0302 clinical medicine, Osteogenesis, Mast Cells, Systemic mastocytosis, Child, Aged, 80 and over, Multidisciplinary, Cell Differentiation, Osteoblast, Middle Aged, Mast cell, RUNX2, Mechanisms of disease, medicine.anatomical_structure, Child, Preschool, 030220 oncology & carcinogenesis, miRNAs, Female, Mastocytosis, Adult, Smad5 Protein, Adolescent, Science, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, Smad1 Protein, Extracellular Vesicles, Young Adult, 03 medical and health sciences, Calcification, Physiologic, medicine, Animals, Humans, Aged, Myeloproliferative Disorders, Osteoblasts, business.industry, General Chemistry, medicine.disease, Mice, Inbred C57BL, MicroRNAs, 030104 developmental biology, Cancer research, Bone marrow, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9788d1d89c4175b69ee4b424f3cb7644Test
https://doaj.org/article/5187de6573944f56922f41e7869f5c9cTest

2

Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma

المؤلفون: Vincenzo Barnaba, Rita De Vito, Cesare Furlanello, Renata Boldrini, Marco Chierici, Loredana Cifaldi, Valeria Lucarini, Ombretta Melaiu, Aurora Castellano, Franco Locatelli, Doriana Fruci, Giuseppe Jurman, Libenzio Adrian Conti

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, T-Lymphocytes, Programmed Cell Death 1 Receptor, Datasets as Topic, General Physics and Astronomy, NK cells, Settore MED/04, Dendritic cells, B7-H1 Antigen, natural-killer cells, Cohort Studies, Transcriptome, Neuroblastoma, 0302 clinical medicine, Tumor Microenvironment, Killer Cells, Lymphocytes, RNA-Seq, Child, Multidisciplinary, Middle Aged, Prognosis, Killer Cells, Natural, Survival Rate, tumor-infiltrating dendritic cells, medicine.anatomical_structure, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Child, Preschool, 030220 oncology & carcinogenesis, Natural, Female, Cancer microenvironment, Adult, Adolescent, T cell, Science, Biology, Sensitivity and Specificity, Article, Disease-Free Survival, General Biochemistry, Genetics and Molecular Biology, Natural killer cell, Paediatric cancer, Young Adult, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Immune system, medicine, Humans, Tumor-Infiltrating, Preschool, Tumor microenvironment, Infant, General Chemistry, Dendritic cell, medicine.disease, 030104 developmental biology, Cancer research, neuroblastoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570d8fd58fb1623fcd54b30696e96edfTest
https://doaj.org/article/191708cfe4614fcda62e11c1850f8185Test

3

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

المؤلفون: Peter Carmeliet, Louise Deldicque, Sunghoon Kim, Shimin Zhao, Leigh Breen, Gillian Fitzgerald, Koen Veys, Peppi Koivunen, Benoit Smeuninx, Inés Soro-Arnaiz, Katrien De Bock, Bert Blaauw, Gommaar D'Hulst, Evi Masschelein

المساهمون: UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11
Nature Communications
Nature Communications, Vol. 11, no. 1, p. 174 (2020)

مصطلحات موضوعية: 0301 basic medicine, Male, Aging, Regulator, General Physics and Astronomy, mTORC1, Inbred C57BL, Muscle Development, Hydroxylation, chemistry.chemical_compound, Mice, 0302 clinical medicine, Amino Acids, lcsh:Science, Mice, Knockout, chemistry.chemical_classification, Multidisciplinary, Muscles, Amino acid, Cell biology, Mechanisms of disease, TOR signalling, Female, Leucine, Signal transduction, biological phenomena, cell phenomena, and immunity, Signal Transduction, Gene isoform, Adult, Knockout, Science, Procollagen-Proline Dioxygenase, Genetics and Molecular Biology, Mechanistic Target of Rapamycin Complex 1, Article, General Biochemistry, Genetics and Molecular Biology, Hypoxia-Inducible Factor-Proline Dioxygenases, 03 medical and health sciences, Clinical Research, Animals, Humans, Aged, Animal, Leucyl-tRNA synthetase, General Chemistry, Mice, Inbred C57BL, Oxygen, Disease Models, Animal, 030104 developmental biology, HEK293 Cells, chemistry, Preclinical research, General Biochemistry, Disease Models, lcsh:Q, Leucine-tRNA Ligase, 030217 neurology & neurosurgery

وصف الملف: Electronic; application/pdf; application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed65d3a9ba21caa35226b725b5c4e464Test
https://doaj.org/article/57ce964136154da49cd0e8f1b72242c1Test

4

Genomic and immune profiling of pre-invasive lung adenocarcinoma

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Lung Neoplasms, Receptor, ErbB-2, MAP Kinase Kinase 1, Loss of Heterozygosity, General Physics and Astronomy, medicine.disease_cause, Loss of heterozygosity, 0302 clinical medicine, HLA Antigens, lcsh:Science, Exome, Exome sequencing, Cancer, Aged, 80 and over, Multidisciplinary, RNA-Binding Proteins, Middle Aged, Proto-Oncogene Proteins c-met, 3. Good health, ErbB Receptors, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, KRAS, Adult, Proto-Oncogene Proteins B-raf, DNA Copy Number Variations, Science, Receptors, Antigen, T-Cell, Receptors, Antigen, B-Cell, Adenocarcinoma of Lung, Adenocarcinoma in Situ, Human leukocyte antigen, Biology, Malignancy, Article, General Biochemistry, Genetics and Molecular Biology, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Exome Sequencing, Genetics, medicine, Humans, Neoplasm Invasiveness, neoplasms, Aged, Gene Expression Profiling, General Chemistry, medicine.disease, digestive system diseases, Gene expression profiling, 030104 developmental biology, Mutation, Cancer research, lcsh:Q, Tumor Suppressor Protein p53

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e869032752dccbe620cc15973c500df4Test
http://link.springer.com/article/10.1038/s41467-019-13460-3Test

5

Liquid biopsy-based single-cell metabolic phenotyping of lung cancer patients for informative diagnostics

المؤلفون: Yu Dong, Ziming Li, Chunying Wang, Qihui Shi, Yin Tang, Jie Chen, Shun Lu, Baojun Wu, Xiang Lu, Zhuo Wang, Min Xue, Liu Yang, Zhili Guo, Wei Wei

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Lung Neoplasms, medicine.medical_treatment, General Physics and Astronomy, Cell Count, Kaplan-Meier Estimate, 02 engineering and technology, B7-H1 Antigen, Targeted therapy, Transcriptome, lcsh:Science, Aged, 80 and over, Multidisciplinary, Biological techniques, Middle Aged, Prognosis, 021001 nanoscience & nanotechnology, Cancer metabolism, Cell killing, Adenocarcinoma, Female, Single-Cell Analysis, 0210 nano-technology, Adult, Tumour heterogeneity, Science, Adenocarcinoma of Lung, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Medical research, Proto-Oncogene Proteins, Biomarkers, Tumor, medicine, Humans, Metabolomics, Liquid biopsy, Lung cancer, Aged, business.industry, Gene Expression Profiling, Liquid Biopsy, Receptor Protein-Tyrosine Kinases, General Chemistry, Microarray Analysis, Programmed Cell Death 1 Ligand 2 Protein, medicine.disease, Axl Receptor Tyrosine Kinase, Immune checkpoint, Pleural Effusion, Malignant, 030104 developmental biology, Cancer research, lcsh:Q, business, Non-small-cell lung cancer, Cytometry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2a2ec472bb45bd704b980482fcddd5Test
https://doaj.org/article/fc6306e74458427db8cad26bd5b3ccb6Test

6

Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis

المؤلفون: Shuo Li, Edward B. Garon, Frank Alber, Xiaohui Ni, Steven M. Dubinett, Yonggang Zhou, Wing Hung Wong, Weihua Zeng, Mary L. Stackpole, Wenyuan Li, Xianghong Jasmine Zhou, Vatche G. Agopian, Zuyang Yuan, Zorawar S. Noor

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature communications, vol 12, iss 1

مصطلحات موضوعية: 0301 basic medicine, Male, Statistical methods, medicine.medical_treatment, Biopsy, DNA Mutational Analysis, Programmed Cell Death 1 Receptor, Drug Resistance, General Physics and Astronomy, Datasets as Topic, Circulating Tumor DNA, 0302 clinical medicine, Neoplasms, Monoclonal, Cancer genomics, Humanized, Immune Checkpoint Inhibitors, Exome sequencing, Cancer, screening and diagnosis, Tumor, Multidisciplinary, Single Nucleotide, Middle Aged, Prognosis, Progression-Free Survival, Detection, 030220 oncology & carcinogenesis, Mutation (genetic algorithm), Biomarker (medicine), Female, 4.2 Evaluation of markers and technologies, Adult, Science, Sequencing data, Computational biology, Antibodies, Monoclonal, Humanized, Polymorphism, Single Nucleotide, Sensitivity and Specificity, Antibodies, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Exome Sequencing, Genetics, medicine, Biomarkers, Tumor, Humans, Computer Simulation, Genetic Testing, Progression-free survival, Polymorphism, business.industry, Human Genome, General Chemistry, Patient data, Immunotherapy, medicine.disease, 4.1 Discovery and preclinical testing of markers and technologies, Computational biology and bioinformatics, Good Health and Well Being, 030104 developmental biology, Drug Resistance, Neoplasm, Mutation, Neoplasm, business, Biomarkers, Software

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78118c6a69c156d0987bbf4bddc8d970Test
http://europepmc.org/articles/PMC8263778Test

7

Neuroepigenetic signatures of age and sex in the living human brain

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Emotions, Histone Deacetylase 2, General Physics and Astronomy, Hippocampus, Adamantane, Histone Deacetylase 1, 02 engineering and technology, Hydroxamic Acids, Epigenesis, Genetic, Carbon Radioisotopes, Epigenetics in the nervous system, lcsh:Science, Sex Characteristics, Martinostat, Multidisciplinary, biology, Histone deacetylase 2, Age Factors, Brain, Human brain, Middle Aged, 021001 nanoscience & nanotechnology, White Matter, Tissue Donors, medicine.anatomical_structure, Histone, Female, 0210 nano-technology, Sex characteristics, Adult, medicine.medical_specialty, Adolescent, Science, Article, General Biochemistry, Genetics and Molecular Biology, White matter, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, Epigenetics, Aged, General Chemistry, 030104 developmental biology, Endocrinology, biology.protein, lcsh:Q, Positron-emission tomography

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66db91f6dcd6bbc9b339b5bacf19546dTest
https://doaj.org/article/fd891fe0074148ad83476fb18c8b1d21Test

8

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

المؤلفون: Hiroshi Asahara, Yoshiaki Ito, Tokio Matsuzaki, Kohei Miyata, Tempei Sato, Martin Lotz, Ryo Nakamichi, Merissa Olmer, Eiji Sugiyama, Masafumi Inui, Sho Mokuda

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Cartilage, Articular, CRISPR-Cas9 genome editing, Knee Joint, Ubiquitylation, General Physics and Astronomy, Core Binding Factor Alpha 1 Subunit, 02 engineering and technology, Osteoarthritis, Menisci, Tibial, Mice, Ubiquitin, lcsh:Science, Aged, 80 and over, Mice, Knockout, Multidisciplinary, biology, Cartilage homeostasis, Chemistry, Middle Aged, 021001 nanoscience & nanotechnology, musculoskeletal system, Ubiquitin ligase, Cell biology, RUNX2, medicine.anatomical_structure, miRNAs, 0210 nano-technology, Signal Transduction, Adult, musculoskeletal diseases, Ubiquitin-Protein Ligases, Science, WWP2, macromolecular substances, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Young Adult, Downregulation and upregulation, medicine, Animals, Humans, RNA, Messenger, Aged, Cartilage, Skull, Ubiquitination, General Chemistry, X-Ray Microtomography, medicine.disease, Arthritis, Experimental, Disease Models, Animal, 030104 developmental biology, biology.protein, lcsh:Q, ADAMTS5 Protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4c9bffffe46cfae2df3f937bdfb3f0Test
http://link.springer.com/article/10.1038/s41467-019-10177Test-1

9

Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling

المؤلفون: Chiou-Hwa Yuh, Shih Sheng Jiang, Chun Nan OuYang, Ngan Ming Tsang, Shu Chen Liu, Tien Hsu, An Ko Chung, Yu-Sun Chang, Ya Ping Liu, Chuen Hsueh

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Male, General Physics and Astronomy, Mice, SCID, Leukemia Inhibitory Factor, Metastasis, Mice, Neoplasm Metastasis, lcsh:Science, reproductive and urinary physiology, YAP1, Aged, 80 and over, Multidisciplinary, Nasopharyngeal Carcinoma, Kinase, Chemistry, Signal transducing adaptor protein, Middle Aged, Immunohistochemistry, embryonic structures, Female, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, Adult, endocrine system, Epithelial-Mesenchymal Transition, Receptors, OSM-LIF, Science, Blotting, Western, General Biochemistry, Genetics and Molecular Biology, Article, Focal adhesion, 03 medical and health sciences, Young Adult, medicine, Human Umbilical Vein Endothelial Cells, otorhinolaryngologic diseases, Animals, Humans, Neoplasm Invasiveness, Adaptor Proteins, Signal Transducing, Aged, urogenital system, Cancer, Nasopharyngeal Neoplasms, YAP-Signaling Proteins, General Chemistry, medicine.disease, Phosphoproteins, Xenograft Model Antitumor Assays, stomatognathic diseases, 030104 developmental biology, Nasopharyngeal carcinoma, Focal Adhesion Kinase 1, Cancer research, lcsh:Q, Paxillin, Leukemia inhibitory factor, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de69d2972cda5f8e3890c7fa1222a2d4Test
http://link.springer.com/article/10.1038/s41467-018-07660-6Test

10

TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Gomes, C, Gayden, T, Bajic, A, Harraz, O, Pratt, J, Nikbakht, H, Bareke, E, Goncalves, M, Castro, W, St-Onge, P, Sinnett, D, Han, H, Rivera, B, Mikael, L, DeJay, N, Kleinman, C, Valera, E, Bassenden, A, Berghuis, A, Majewski, J, Nelson, M, Gomez, R & Jabado, N 2018, ' TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw ', Nature Communications, vol. 9, no. 1, pp. 4572 . https://doi.org/10.1038/s41467-018-06690-4Test
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, Patch-Clamp Techniques, Somatic cell, General Physics and Astronomy, medicine.disease_cause, Jaw Neoplasms/genetics, Whole Exome Sequencing, Receptor, Child, lcsh:Science, Exome sequencing, Giant Cell Tumor of Bone, Multidisciplinary, High-Throughput Nucleotide Sequencing, Middle Aged, Jaw Neoplasms, 3. Good health, Gain of Function Mutation, Female, KRAS, TRPV4, Adult, Giant Cell Tumor of Bone/genetics, Adolescent, MAP Kinase Signaling System, Science, TRPV Cation Channels, TRPV Cation Channels/genetics, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Proto-Oncogene Proteins p21(ras), Proto-Oncogene Proteins p21(ras)/genetics, 03 medical and health sciences, Young Adult, Exome Sequencing, medicine, Humans, Computer Simulation, Receptor, Fibroblast Growth Factor, Type 1, Aged, Receptor, Fibroblast Growth Factor, Type 1/genetics, Sequence Analysis, RNA, HEK 293 cells, General Chemistry, Sequence Analysis, DNA, stomatognathic diseases, 030104 developmental biology, HEK293 Cells, Giant cell, Cancer research, lcsh:Q

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be0322012f1773bb260e639e107111bTest
http://link.springer.com/article/10.1038/s41467-018-06690-4Test

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