Corrigendum: Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
| العنوان: | Corrigendum: Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation |
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| المؤلفون: | Zemin Zhang, Hongwei Yao, Yonglu Tian, Yongfeng Yang, Chuanzhen Yang, Yapeng Ji, Xi Zhu, Xiaofeng Zheng, Zefang Tang, Jiafu Ji |
| المصدر: | Nature Communications Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017) |
| بيانات النشر: | Nature Publishing Group, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Colorectal cancer, Carcinogenesis, General Physics and Astronomy, 02 engineering and technology, Self renewal, 01 natural sciences, Mice, Phosphorylation, RNA, Small Interfering, Multidisciplinary, Nuclear Proteins, 021001 nanoscience & nanotechnology, Corrigenda, Spelling, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Isoenzymes, Phenotype, Doxycycline, Neoplastic Stem Cells, Stem cell, 0210 nano-technology, Colorectal Neoplasms, Glycolysis, Protein Binding, Science, Zhàng, Adenylate kinase, Mice, Nude, Antineoplastic Agents, Biology, 010402 general chemistry, General Biochemistry, Genetics and Molecular Biology, medicine, Animals, Humans, Neoplasm Invasiveness, L-Lactate Dehydrogenase, General Chemistry, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, Drug Resistance, Neoplasm, Cancer research, Tyrosine, Lactate Dehydrogenase 5, Reactive Oxygen Species, Protein Processing, Post-Translational |
| الوصف: | Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is an innovative therapeutic strategy for colorectal cancer (CRC) patients with poor prognosis and relapse. However, the context-dependent metabolic traits of CRCSCs remain poorly elucidated. Here we report that adenylate kinase hCINAP is overexpressed in CRC tissues. Depletion of hCINAP inhibits invasion, self-renewal, tumorigenesis and chemoresistance of CRCSCs with a loss of mesenchymal signature. Mechanistically, hCINAP binds to the C-terminal domain of LDHA, the key regulator of glycolysis, and depends on its adenylate kinase activity to promote LDHA phosphorylation at tyrosine 10, resulting in the hyperactive Warburg effect and the lower cellular ROS level and conferring metabolic advantage to CRCSC invasion. Moreover, hCINAP expression is positively correlated with the level of Y10-phosphorylated LDHA in CRC patients. This study identifies hCINAP as a potent modulator of metabolic reprogramming in CRCSCs and a promising drug target for CRC invasion and metastasis. |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa2b255fbd39688ba26e6b5a5892568Test http://europepmc.org/articles/PMC5481747Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....caa2b255fbd39688ba26e6b5a5892568 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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