نتائج البحث

1

Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

المؤلفون: Geethani Bandara, Young-Eun Cho, Do-Kyun Kim, Ho Min Kim, Ana Olivera, Moon-Chang Baek, Dean D. Metcalfe, Baktiar Karim, Danielle R. Donahue, Hirsh D. Komarow

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Bone disease, Cellular differentiation, Osteoporosis, General Physics and Astronomy, Core Binding Factor Alpha 1 Subunit, Myeloproliferative disease, Mice, 0302 clinical medicine, Osteogenesis, Mast Cells, Systemic mastocytosis, Child, Aged, 80 and over, Multidisciplinary, Cell Differentiation, Osteoblast, Middle Aged, Mast cell, RUNX2, Mechanisms of disease, medicine.anatomical_structure, Child, Preschool, 030220 oncology & carcinogenesis, miRNAs, Female, Mastocytosis, Adult, Smad5 Protein, Adolescent, Science, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, Smad1 Protein, Extracellular Vesicles, Young Adult, 03 medical and health sciences, Calcification, Physiologic, medicine, Animals, Humans, Aged, Myeloproliferative Disorders, Osteoblasts, business.industry, General Chemistry, medicine.disease, Mice, Inbred C57BL, MicroRNAs, 030104 developmental biology, Cancer research, Bone marrow, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9788d1d89c4175b69ee4b424f3cb7644Test
https://doaj.org/article/5187de6573944f56922f41e7869f5c9cTest

2

Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma

المؤلفون: Vincenzo Barnaba, Rita De Vito, Cesare Furlanello, Renata Boldrini, Marco Chierici, Loredana Cifaldi, Valeria Lucarini, Ombretta Melaiu, Aurora Castellano, Franco Locatelli, Doriana Fruci, Giuseppe Jurman, Libenzio Adrian Conti

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, T-Lymphocytes, Programmed Cell Death 1 Receptor, Datasets as Topic, General Physics and Astronomy, NK cells, Settore MED/04, Dendritic cells, B7-H1 Antigen, natural-killer cells, Cohort Studies, Transcriptome, Neuroblastoma, 0302 clinical medicine, Tumor Microenvironment, Killer Cells, Lymphocytes, RNA-Seq, Child, Multidisciplinary, Middle Aged, Prognosis, Killer Cells, Natural, Survival Rate, tumor-infiltrating dendritic cells, medicine.anatomical_structure, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Child, Preschool, 030220 oncology & carcinogenesis, Natural, Female, Cancer microenvironment, Adult, Adolescent, T cell, Science, Biology, Sensitivity and Specificity, Article, Disease-Free Survival, General Biochemistry, Genetics and Molecular Biology, Natural killer cell, Paediatric cancer, Young Adult, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Immune system, medicine, Humans, Tumor-Infiltrating, Preschool, Tumor microenvironment, Infant, General Chemistry, Dendritic cell, medicine.disease, 030104 developmental biology, Cancer research, neuroblastoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570d8fd58fb1623fcd54b30696e96edfTest
https://doaj.org/article/191708cfe4614fcda62e11c1850f8185Test

3

Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination

المؤلفون: Florian Krammer, Saskia Killmer, Christoph Neumann-Haefelin, Bertram Bengsch, Katharina Wild, Katharina Zoldan, Maike Hofmann, Maike Smits, Tobias Boettler, Robert Thimme, Shirin Strohmeier, Martin Schwemmle

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Adult, CD4-Positive T-Lymphocytes, Male, Protein vaccines, T cell, Science, General Physics and Astronomy, Hemagglutinin (influenza), Vaccine-naive, Antibodies, Viral, Lymphocyte Activation, Immunological memory, General Biochemistry, Genetics and Molecular Biology, Epitope, Article, Antibodies, Inducible T-Cell Co-Stimulator Protein, Young Adult, Immunity, T-Lymphocyte Subsets, Influenza, Human, medicine, Humans, Cells, Cultured, Multidisciplinary, Membrane Glycoproteins, biology, Influenza A Virus, H3N2 Subtype, Vaccination, General Chemistry, Middle Aged, ADP-ribosyl Cyclase 1, medicine.anatomical_structure, Hemagglutinins, Immunization, Influenza Vaccines, Immunoglobulin G, Immunology, biology.protein, Female, Seasons, Antibody

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fcb2b2bd703c4f63ffa01c40c65e10Test
http://europepmc.org/articles/PMC8602312Test

4

Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer

المؤلفون: Hayri E. Balcioglu, Iris Nederlof, Mieke Timmermans, John W.M. Martens, Reno Debets, Renée Foekens, Olga I. Isaeva, Rebecca Wijers, Hugo M. Horlings, Marcel Smid, Anita M. A. C. Trapman-Jansen, Dora Hammerl, Roberto Salgado, Leonie Voorwerk, Marleen Kok

المساهمون: Medical Oncology

المصدر: Nature Communications, 12(1):5668. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications

مصطلحات موضوعية: Adult, T-Lymphocytes, Science, T cell, Programmed Cell Death 1 Receptor, Immunology, Cell, Antigens, Differentiation, Myelomonocytic, Datasets as Topic, General Physics and Astronomy, Receptors, Cell Surface, Triple Negative Breast Neoplasms, Diseases, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Immunophenotyping, Cohort Studies, Lymphocytes, Tumor-Infiltrating, Medical research, Immune system, SDG 3 - Good Health and Well-being, Antigens, CD, Tumor Microenvironment, medicine, Humans, Breast, RNA-Seq, Receptor, Immune Checkpoint Inhibitors, Wnt Signaling Pathway, Mastectomy, Triple-negative breast cancer, Cancer, Spatial Analysis, Multidisciplinary, T-cell receptor, Wnt signaling pathway, General Chemistry, Prognosis, Phenotype, Neoadjuvant Therapy, medicine.anatomical_structure, Drug Resistance, Neoplasm, Cancer research, Female, Tumor Escape, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8530b84ca13ab7128ec85fda20aeb5c6Test
https://pure.eur.nl/en/publications/eb2a9c63-0754-4f32-b5b4-85ff2d2d7052Test

5

Neuroepigenetic signatures of age and sex in the living human brain

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Emotions, Histone Deacetylase 2, General Physics and Astronomy, Hippocampus, Adamantane, Histone Deacetylase 1, 02 engineering and technology, Hydroxamic Acids, Epigenesis, Genetic, Carbon Radioisotopes, Epigenetics in the nervous system, lcsh:Science, Sex Characteristics, Martinostat, Multidisciplinary, biology, Histone deacetylase 2, Age Factors, Brain, Human brain, Middle Aged, 021001 nanoscience & nanotechnology, White Matter, Tissue Donors, medicine.anatomical_structure, Histone, Female, 0210 nano-technology, Sex characteristics, Adult, medicine.medical_specialty, Adolescent, Science, Article, General Biochemistry, Genetics and Molecular Biology, White matter, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, Epigenetics, Aged, General Chemistry, 030104 developmental biology, Endocrinology, biology.protein, lcsh:Q, Positron-emission tomography

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66db91f6dcd6bbc9b339b5bacf19546dTest
https://doaj.org/article/fd891fe0074148ad83476fb18c8b1d21Test

6

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

المؤلفون: Hiroshi Asahara, Yoshiaki Ito, Tokio Matsuzaki, Kohei Miyata, Tempei Sato, Martin Lotz, Ryo Nakamichi, Merissa Olmer, Eiji Sugiyama, Masafumi Inui, Sho Mokuda

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Cartilage, Articular, CRISPR-Cas9 genome editing, Knee Joint, Ubiquitylation, General Physics and Astronomy, Core Binding Factor Alpha 1 Subunit, 02 engineering and technology, Osteoarthritis, Menisci, Tibial, Mice, Ubiquitin, lcsh:Science, Aged, 80 and over, Mice, Knockout, Multidisciplinary, biology, Cartilage homeostasis, Chemistry, Middle Aged, 021001 nanoscience & nanotechnology, musculoskeletal system, Ubiquitin ligase, Cell biology, RUNX2, medicine.anatomical_structure, miRNAs, 0210 nano-technology, Signal Transduction, Adult, musculoskeletal diseases, Ubiquitin-Protein Ligases, Science, WWP2, macromolecular substances, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Young Adult, Downregulation and upregulation, medicine, Animals, Humans, RNA, Messenger, Aged, Cartilage, Skull, Ubiquitination, General Chemistry, X-Ray Microtomography, medicine.disease, Arthritis, Experimental, Disease Models, Animal, 030104 developmental biology, biology.protein, lcsh:Q, ADAMTS5 Protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4c9bffffe46cfae2df3f937bdfb3f0Test
http://link.springer.com/article/10.1038/s41467-019-10177Test-1

7

Regulation of miR-181a expression in T cell aging

المؤلفون: Rohit R. Jadhav, Guangjin Li, Bin Hu, Chulwoo Kim, Zhongde Ye, Jörg J. Goronzy, Cornelia M. Weyand

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Adult, Science, T cell, T-Lymphocytes, General Physics and Astronomy, Transcription factor complex, Biology, Lymphocyte Activation, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Young Adult, microRNA, medicine, Transcriptional regulation, Gene silencing, Humans, Enhancer, lcsh:Science, Cellular Senescence, YY1 Transcription Factor, Aged, Aged, 80 and over, Multidisciplinary, T-cell receptor, Cell Differentiation, General Chemistry, Cell biology, Up-Regulation, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, HEK293 Cells, Chromosomes, Human, Pair 1, embryonic structures, lcsh:Q, Signal transduction, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787911c3b4459e1342a21b4538574870Test
http://link.springer.com/article/10.1038/s41467-018-05552-3Test

8

Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis

المؤلفون: Hiromi Yamaguchi, Shinji Oki, Kimitoshi Kimura, Masashi Fukuoka, Chiharu Tomi, Wakiro Sato, Takashi Yamamura, Ryosuke Takahashi, Hirohiko Hohjoh, Takayuki Kondo

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications

مصطلحات موضوعية: Adult, CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Multiple Sclerosis, Regulatory T cell, Science, Receptor, Transforming Growth Factor-beta Type I, General Physics and Astronomy, Protein Serine-Threonine Kinases, Exosomes, T-Lymphocytes, Regulatory, Exosome, Article, General Biochemistry, Genetics and Molecular Biology, Receptor, IGF Type 1, 03 medical and health sciences, 0302 clinical medicine, microRNA, medicine, Humans, lcsh:Science, Insulin-like growth factor 1 receptor, Multidisciplinary, biology, Multiple sclerosis, Interleukin-17, FOXP3, Forkhead Transcription Factors, Receptors, Somatomedin, General Chemistry, Transforming growth factor beta, Middle Aged, medicine.disease, Microvesicles, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, biology.protein, Cancer research, Female, lcsh:Q, Transcriptome, Receptors, Transforming Growth Factor beta, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2390486c8fbd843bbd0bb3d9c0666fTest
http://hdl.handle.net/2433/235236Test

9

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

المؤلفون: Takehiro Suzuki, Yotaro Matsumoto, Chikahisa Mukawa, Tomoya Tsukimi, Jun Wada, Hiroki Tsukamoto, Yuji Oe, Takaaki Abe, Naoto Suzuki, Nobuyuki Takahashi, Tetsuro Matsuhashi, Yuji Owada, Jurgen Heymann, Hiroaki Yamaguchi, Yukako Akiyama, Chitose Suzuki, Paxton Thanai, Ritsumi Saito, Satoshi Shimada, Ching Chin Yang, Tomohiro Nakamura, Fumika Nanto-Hara, Susumu Ogawa, Daisuke Saigusa, Matthew C. Breeggemann, Koichi Kikuchi, Masayuki Yamamoto, Akihiro Matsuo, Yoshitomi Kanemitsu, Jeffrey B. Kopp, Shinji Fukuda, Sadayoshi Ito, Tomoyuki Iwasaki, Yasutoshi Akiyama, Mariko Ichijo, Atsushi Hozawa, Miho Shimizu, Toshihiro Sato, Takafumi Toyohara, Yoshihisa Tomioka, Tomoyoshi Soga, Yoshiaki Ogata, Nariyasu Mano, Koki Mise, Jiro Ogura, Eikan Mishima, Noriko N. Fukuda, Takashi Suzuki, Shizuko Nagao, Kei Asaji, Takashi Wada, Yusuke Ohsaki, Hisato Shima, Hsin Jung Ho, Yoshitsugu Oikawa, Shigeo Kure

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

مصطلحات موضوعية: 0301 basic medicine, Male, General Physics and Astronomy, Organic Anion Transporters, 02 engineering and technology, Diabetic nephropathy, urologic and male genital diseases, Podocyte, Madin Darby Canine Kidney Cells, Animals, Genetically Modified, Cohort Studies, Mice, Diabetic Nephropathies, Enzyme Inhibitors, lcsh:Science, Tyrosine Phenol-Lyase, Aged, 80 and over, Kidney, Multidisciplinary, Proteinuria, Podocytes, Sulfates, Middle Aged, 021001 nanoscience & nanotechnology, medicine.anatomical_structure, Female, medicine.symptom, 0210 nano-technology, Adult, medicine.medical_specialty, Science, Sulfuric Acid Esters, General Biochemistry, Genetics and Molecular Biology, Streptozocin, Article, Diabetes Mellitus, Experimental, 03 medical and health sciences, Young Adult, Dogs, Diabetes mellitus, Internal medicine, medicine, Diabetes Mellitus, Animals, Metabolomics, Albuminuria, Humans, Aged, business.industry, urogenital system, General Chemistry, medicine.disease, Rats, Gastrointestinal Microbiome, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 1, Early Diagnosis, Diabetes Mellitus, Type 2, lcsh:Q, Microalbuminuria, Microbiome, business, Kidney disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53539ee350baef3ab3064425f4e6578Test
http://europepmc.org/articles/PMC6478834Test

10

Oxytocin pathway gene networks in the human brain

المؤلفون: Lars T. Westlye, Tobias Kaufmann, Ole A. Andreassen, Ingrid Dieset, Dag Alnæs, Daniel Quintana, Aldo Córdova-Palomera, Jaroslav Rokicki, Dennis van der Meer

المساهمون: Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, 10:668. Nature Publishing Group
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Receptor expression, Gene regulatory network, General Physics and Astronomy, VASOPRESSIN, 02 engineering and technology, Oxytocin, INTRANASAL OXYTOCIN, DOPAMINE, GLUTAMATE, Cognition, SCHIZOPHRENIA, lcsh:Science, Multidisciplinary, Dopaminergic, Oxytocin secretion, RECEPTOR EXPRESSION, SOCIAL ATTACHMENT, Brain, Human brain, Middle Aged, 021001 nanoscience & nanotechnology, Magnetic Resonance Imaging, medicine.anatomical_structure, Receptors, Oxytocin, Female, 0210 nano-technology, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Adult, endocrine system, Science, NUCLEUS-ACCUMBENS, Hypothalamus, Neuropeptide, Biology, MICE LACKING, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Humans, RNA, Messenger, OLFACTORY-BULB, General Chemistry, ADP-ribosyl Cyclase 1, Oxytocin receptor, 030104 developmental biology, lcsh:Q, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0be5a2a5c06adadb66c62479719fc4dTest
https://doi.org/10.1038/s41467-019-08503-8Test

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