COPII and the regulation of protein sorting in mammals
| العنوان: | COPII and the regulation of protein sorting in mammals |
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| المؤلفون: | Kanika Bajaj Pahuja, Soomin Shim, Sean Studer, Randy Schekman, Giulia Zanetti |
| المصدر: | Nature Cell Biology. 14:20-28 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Mammals, Secretory Pathway, Vesicular-tubular cluster, Endoplasmic reticulum, Golgi Apparatus, Cell Biology, COPI, Golgi apparatus, Biology, Endoplasmic Reticulum, medicine.disease_cause, Transport protein, Cell biology, Protein Transport, symbols.namesake, Secretory protein, Protein targeting, symbols, medicine, Animals, Humans, COP-Coated Vesicles, COPII |
| الوصف: | Secretory proteins are transported to the Golgi complex in vesicles that bud from the endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved throughout all eukaryotes. Nevertheless, the COPII coat has adapted to the higher complexity of mammalian physiology, achieving more sophisticated levels of secretory regulation. In this review we cover aspects of mammalian COPII-mediated regulation of secretion, in particular related to the function of COPII paralogues, the spatial organization of cargo export and the role of accessory proteins. |
| تدمد: | 1476-4679 1465-7392 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10d32adeb056f90eca7929c68996fd0Test https://doi.org/10.1038/ncb2390Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a10d32adeb056f90eca7929c68996fd0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764679 14657392 |
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