المؤلفون: Gad Getz, James M. McFarland, Aviad Tsherniak, Francisca Vazquez, Benjamin Gaeta, Yosef E. Maruvka, Marios Giannakis, Mirazul Islam, Monica Schenone, Edmond M. Chan, Annie Apffel, Sandy Chang, Paula Keskula, Alfredo Gonzalez, Jesse S. Boehm, Maria Alimova, Justine S. McPartlan, Tsukasa Shibue, Srivatsan Raghavan, Jean-Bernard Lazaro, Peili Gu, Yang Liu, Yanxi Zhang, Elizaveta Reznichenko, Lisa Leung, Jatin Roper, Tianxia Li, David E. Root, Raymond W.S. Ng, Emma A. Roberts, Alan D. D'Andrea, Jie Bin Liu, Syed O. Ali, Todd R. Golub, Zachary D. Nagel, Mahmoud Ghandi, Cortt G. Piett, Adam J. Bass, Nancy Dumont, Yuen-Yi Tseng, Rebecca Deasy

المصدر: Nature

مصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Werner Syndrome Helicase, DNA repair, Apoptosis, Article, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Cell Line, Tumor, Neoplasms, medicine, Humans, Gene silencing, DNA Breaks, Double-Stranded, Polymerase, Multidisciplinary, Models, Genetic, biology, nutritional and metabolic diseases, Helicase, Microsatellite instability, Cell Cycle Checkpoints, medicine.disease, 3. Good health, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Microsatellite Instability, RNA Interference, DNA mismatch repair, CRISPR-Cas Systems, Tumor Suppressor Protein p53, Synthetic Lethal Mutations, Homologous recombination, Microsatellite Repeats

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010920e40e2ec3ff04315a977ff14d2aTest
https://doi.org/10.1038/s41586-019-1102-xTest

المؤلفون: Ryan O’Rourke, Aaron R. Thorner, Francisca Vazquez, Nicholas J. Lyons, Aviad Tsherniak, Peter Tsvetkov, Helen Tang, Anthony J. Garrity, Gavin Ha, Chet Birger, Guillaume Kugener, Craig A. Strathdee, Rameen Beroukhim, Robert Burns, Bang Wong, Pratiti Bandopadhayay, Anwesha Nag, Benjamin A. Siranosian, Andrew A. Tubelli, Todd R. Golub, Mahmoud Ghandi, Matthew Meyerson, Yosef E. Maruvka, Joshua A. Bittker, Joshua M. Dempster, Kunihiko Hinohara, Uri Ben-David, Beth A. Cimini, Yaara Oren, Gad Getz

المساهمون: Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Pourquier, Philippe

المصدر: Bulletin du Cancer
Bulletin du Cancer, John Libbey Eurotext, 2019, 106 (1), pp.9-10. ⟨10.1016/j.bulcan.2018.12.002⟩
Nature

مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, [SDV]Life Sciences [q-bio], Breast Neoplasms, Biology, Article, Genomic Instability, Evolution, Molecular, Mice, 03 medical and health sciences, Transcription (biology), Cell Line, Tumor, Gene expression, Genetic variation, Drug response, Animals, Humans, Cell Shape, ComputingMilieux_MISCELLANEOUS, Cell Proliferation, Genetics, Multidisciplinary, Cell growth, Genetic Variation, Reproducibility of Results, Clone Cells, Organoids, [SDV] Life Sciences [q-bio], 030104 developmental biology, Cell culture, MCF-7 Cells, Cancer cell lines, Clonal selection

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b17c29a39c9395a603088b39eea27b7Test
https://doi.org/10.1038/s41586-018-0409-3Test

المؤلفون: Amber L. Sorenson, Noam Shoresh, Roy Kishony, Franziska Michor, Anna Selmecki, Subhajyoti De, Marie Guillet, Phillip A. Richmond, David Pellman, Robin D. Dowell, Yosef E. Maruvka

المصدر: Nature

مصطلحات موضوعية: Mutation rate, Time Factors, Genetic Fitness, Saccharomyces cerevisiae, Haploidy, Biology, medicine.disease_cause, Article, Polyploidy, Mutation Rate, Gene duplication, medicine, Point Mutation, 2. Zero hunger, Genetics, Multidisciplinary, Point mutation, fungi, Fungal genetics, food and beverages, Aneuploidy, Diploidy, Adaptation, Physiological, Biological Evolution, Clone Cells, Chromosomes, Fungal, Adaptation, Ploidy, Carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746ccc82843ffb6663ca64a3b9f5fb4dTest
http://europepmc.org/articles/PMC4497379Test