التفاصيل البيبلوغرافية
| العنوان: |
Licensing of natural killer cells by host major histocompatibility complex class I molecules. |
| المؤلفون: |
Sungjin Kim, Poursine-Laurent, Jennifer, Truscott, Steven M., Lybarger, Lonnie, Yun-Jeong Song, Liping Yang, French, Anthony R., Sunwoo, John B., Lemieux, Suzanne, Hansen, Ted H., Yokoyama, Wayne M. |
| المصدر: |
Nature; 8/4/2005, Vol. 436 Issue 7051, p709-713, 5p |
| مصطلحات موضوعية: |
KILLER cells, MAJOR histocompatibility complex, CELL-mediated cytotoxicity, VERTEBRATES, ANIMALS, LYMPHOCYTES, LEUCOCYTES, IMMUNOCOMPETENT cells, IMMUNOGENETICS |
| مستخلص: |
Self versus non-self discrimination is a central theme in biology from plants to vertebrates, and is particularly relevant for lymphocytes that express receptors capable of recognizing self-tissues and foreign invaders. Comprising the third largest lymphocyte population, natural killer (NK) cells recognize and kill cellular targets and produce pro-inflammatory cytokines. These potentially self-destructive effector functions can be controlled by inhibitory receptors for the polymorphic major histocompatibility complex (MHC) class I molecules that are ubiquitously expressed on target cells. However, inhibitory receptors are not uniformly expressed on NK cells, and are germline-encoded by a set of polymorphic genes that segregate independently from MHC genes. Therefore, how NK-cell self-tolerance arises in vivo is poorly understood. Here we demonstrate that NK cells acquire functional competence through ‘licensing’ by self-MHC molecules. Licensing involves a positive role for MHC-specific inhibitory receptors and requires the cytoplasmic inhibitory motif originally identified in effector responses. This process results in two types of self-tolerant NK cells—licensed or unlicensed—and may provide new insights for exploiting NK cells in immunotherapy. This self-tolerance mechanism may be more broadly applicable within the vertebrate immune system because related germline-encoded inhibitory receptors are widely expressed on other immune cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
