Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
| العنوان: | Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice |
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| المؤلفون: | Steven M. Singer, Xiaodong Yang, Roland Tisch, Hugh O. McDevitt, Lars Fugger, Roland S. Liblau |
| المصدر: | Nature. 366:72-75 |
| بيانات النشر: | Springer Science and Business Media LLC, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Aging, endocrine system, medicine.medical_specialty, endocrine system diseases, T-Lymphocytes, Glutamate decarboxylase, Mice, Inbred Strains, Nod, Biology, medicine.disease_cause, Autoantigens, Autoimmunity, Islets of Langerhans, Mice, Immune system, Antigen, Cell Movement, Mice, Inbred NOD, Internal medicine, medicine, Animals, Lymphocytes, NOD mice, Immunosuppression Therapy, Autoimmune disease, Multidisciplinary, Glutamate Decarboxylase, medicine.disease, Isoenzymes, Diabetes Mellitus, Type 1, Endocrinology, Female, Insulitis |
| الوصف: | Knowing the autoantigen target(s) in an organ-specific autoimmune disease is essential to understanding its pathogenesis. Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease characterized by lymphocytic infiltration of the islets of Langerhans (insulitis) and destruction of insulin-secreting pancreatic beta-cells. Several beta-cell proteins have been identified as autoantigens, but their importance in the diabetogenic process is not known. The non-obese diabetic (NOD) mouse is a murine model for spontaneous IDDM. Here we determine the temporal sequence of T-cell and antibody responses in NOD mice to a panel of five murine beta-cell antigens and find that antibody and T-cell responses specific for the two isoforms of glutamic acid decarboxylase (GAD) are first detected in 4-week-old NOD mice. This GAD-specific reactivity coincides with the earliest detectable response to an islet extract, and with the onset of insulitis. Furthermore, NOD mice receiving intrathymic injections of GAD65 exhibit markedly reduced T-cell proliferative responses to GAD and to the rest of the panel, in addition to remaining free of diabetes. These results indicate that the spontaneous response to beta-cell antigens arises very early in life and that the anti-GAD immune response has a critical role in the disease process during this period. |
| تدمد: | 1476-4687 0028-0836 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df8d93ea47d9a1a281f646e23a41d7eTest https://doi.org/10.1038/366072a0Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1df8d93ea47d9a1a281f646e23a41d7e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764687 00280836 |
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