Competition favouring inactive over active motor neurons during synapse elimination
| العنوان: | Competition favouring inactive over active motor neurons during synapse elimination |
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| المؤلفون: | Edward M. Callaway, David C. Van Essen, James M. Soha |
| المصدر: | Nature. 328:422-426 |
| بيانات النشر: | Springer Science and Business Media LLC, 1987. |
| سنة النشر: | 1987 |
| مصطلحات موضوعية: | Nervous system, medicine.medical_specialty, media_common.quotation_subject, Neuromuscular Junction, Nerve fiber, Tetrodotoxin, Biology, Neuromuscular junction, Competition (biology), Synapse, Internal medicine, medicine, Animals, media_common, Motor Neurons, Soleus muscle, Multidisciplinary, Muscles, Motor neuron, medicine.anatomical_structure, Hebbian theory, Endocrinology, Synapses, Rabbits, Spinal Nerve Roots, Neuroscience |
| الوصف: | During normal postnatal maturation, mammalian muscles undergo an orderly process of synapse elimination, whereby each muscle fibre loses all but one of the multiple inputs with which it is endowed at birth1. Experimental perturbations that increase or decrease the overall activity of nerve and/or muscle cause a corresponding increase or decrease in the overall rate of neuromuscular synapse elimination2–7. On other grounds it has been suggested that competition among motor neurons is important in determining which synapses survive and which are eliminated1,8–10. Would a difference in activity among the terminals at the same endplate affect the outcome of the competition and not just its rate? We investigated this issue by blocking activity for four days in a small fraction of the motor neurons innervating the neonatal rabbit soleus muscle. Twitch tensions of motor units were subsequently measured for both the active and inactive populations of neurons to assess whether the inactive neurons had lost fewer or more synapses than is normal. We found that inactive motor neurons have a significant advantage compared to active counterparts in control experiments, a finding opposite to that expected if the neuromuscular junction operated by classical 'Hebbian' rules of competition11. |
| تدمد: | 1476-4687 0028-0836 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1fdb8185a883f1fc6ac627432e8d30Test https://doi.org/10.1038/328422a0Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0e1fdb8185a883f1fc6ac627432e8d30 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764687 00280836 |
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