المؤلفون: Bart O. Williams, Wim de Lau, Claudia Y. Janda, James D. Moody, Calvin J. Kuo, Hans Clevers, Dirk Siepe, K. Christopher Garcia, Owen Marecic, Jacob Piehler, Luke T. Dang, Junlei Chang, Xingnan Li, Zhendong A. Zhong, Changjiang You, David Baker, Kelley S. Yan

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research

المصدر: Nature
Nature, 545(7653), 234-237. Nature Publishing Group

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Frizzled, Cellular differentiation, Ligands, Tissue Culture Techniques, Mice, Models, Non-U.S. Gov't, Wnt Signaling Pathway, beta Catenin, Genetics, Medicine(all), Multidisciplinary, biology, Mesenchymal Stromal Cells, Research Support, Non-U.S. Gov't, Wnt signaling pathway, LRP6, LRP5, Cell Differentiation, 3. Good health, Cell biology, Intestines, Organoids, Low Density Lipoprotein Receptor-Related Protein-5, Liver, Low Density Lipoprotein Receptor-Related Protein-6, Hydrophobic and Hydrophilic Interactions, Hepatomegaly, Signal Transduction, Beta-catenin, Research Support, Article, N.I.H, 03 medical and health sciences, Palmitoylation, Research Support, N.I.H., Extramural, Journal Article, Animals, Humans, Cell Lineage, General, Cell Proliferation, Molecular, Extramural, Mesenchymal Stem Cells, Frizzled Receptors, Wnt Proteins, 030104 developmental biology, HEK293 Cells, Solubility, Catenin, biology.protein, Hepatocytes, Protein Multimerization

وصف الملف: image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1697ae0891aa810497a623fea42702f7Test
https://hdl.handle.net/20.500.11755/c0057540-d2b0-4d0a-8337-b03099710eaeTest

المؤلفون: Keith T. Flaherty, Claire Song, Sergio Randell, Jingwen Zeng, Gao Zhang, Wei Guo, Wei Zhang, Katrin Sproesser, Meenhard Herlyn, Lynn M. Schuchter, Gordon B. Mills, Yiling Lu, Xiaowei Xu, Yueyao Zhu, Yu-Sheng Cong, Jianglan Liu, Wei Xu, Jonathan Chernoff, Bin Wu, Ravi K. Amaravadi, Wenqun Zhong, Norah Sadek, Benchun Miao, Ryan J. Sullivan, Min Xiao, Shujing Liu, Giorgos C. Karakousis, Jephrey Y. Liu, Chaoran Cheng, Clemens Krepler, Jie Zhang, Genevieve M. Boland, Zhi Wei, Xiaoming Liu, Lawrence W. Wu, Chen Gang, Jeffrey Field, Hezhe Lu, Jun Guo, Yi Hu, Dennie T. Frederick

المصدر: Nature. 550:133-136

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, 0301 basic medicine, MAPK/ERK pathway, MAP Kinase Signaling System, Apoptosis, Drug resistance, Pharmacology, Mitogen-activated protein kinase kinase, Biology, Mice, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, Phosphorylation, p21-activated kinases, Melanoma, Protein Kinase Inhibitors, beta Catenin, PI3K/AKT/mTOR pathway, Mitogen-Activated Protein Kinase Kinases, Multidisciplinary, Kinase, TOR Serine-Threonine Kinases, JNK Mitogen-Activated Protein Kinases, medicine.disease, 3. Good health, Enzyme Activation, Proto-Oncogene Proteins c-raf, 030104 developmental biology, p21-Activated Kinases, Drug development, Drug Resistance, Neoplasm, Mutation, Female, Mitogen-Activated Protein Kinases, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a119a947e1350eea30ef70c168e2b74cTest
https://doi.org/10.1038/nature24040Test

المؤلفون: Naniye Malli Cetinbas, Xin Gu, Wen Xue, Katherine Wu, Milton R. Cornwall-Brady, Ömer H. Yilmaz, Pekka Katajisto, Tuomas Tammela, Yoona K Park, Natanya R. Kerper, Nikhil S. Joshi, Leah Marie Schmidt, Arjun Bhutkar, Katja Helenius, Tyler Jacks, Francisco J. Sánchez-Rivera, Roxana Azimi, R. Alexander Wesselhoeft

المصدر: Nature

مصطلحات موضوعية: Male, 0301 basic medicine, Lung Neoplasms, Beta-catenin, Tumour heterogeneity, Cell, Adenocarcinoma of Lung, Adenocarcinoma, Article, Small Molecule Libraries, Mice, 03 medical and health sciences, Cancer stem cell, medicine, Animals, Humans, Stem Cell Niche, Wnt Signaling Pathway, Cell Proliferation, Multidisciplinary, biology, Wnt signaling pathway, medicine.disease, 3. Good health, Survival Rate, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, Immunology, Cancer cell, Disease Progression, Neoplastic Stem Cells, Cancer research, biology.protein, Female, Stem cell, Protein Processing, Post-Translational, Neoplasm Transplantation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892725b1a04a70b7922a8eae81967b73Test
https://doi.org/10.1038/nature22334Test

المؤلفون: Arnold Han, Xiao Li, Solongo B. Ziraldo, Michael Snyder, Aaron J. W. Hsueh, Tarjei S. Mikkelsen, Kathryn A. Larkin, Vincent C. Luca, Julie Wilhelmy, Akifumi Ootani, Heather Ordonez, Luis A. Chia, Kelly Roelf, Mark Lee, Christopher R. Bolen, Junlei Chang, Hiroo Ueno, Calvin J. Kuo, Susan J. Henning, Paige S. Davies, Jessica M. Terry, Kelley S. Yan, Jenny Yuan, Phillip Belgrader, K. Christopher Garcia, Melissa H. Wong, Amanda T. Mah, Irving L. Weissman, Claudia Y. Janda, Grace X.Y. Zheng, Richard J. von Furstenberg

المصدر: Nature. 545:238-242

مصطلحات موضوعية: 0301 basic medicine, Genetics, Frizzled, Multidisciplinary, Beta-catenin, biology, Receptor expression, Wnt signaling pathway, LGR5, LRP6, LRP5, Hedgehog signaling pathway, Cell biology, 03 medical and health sciences, 030104 developmental biology, biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5aa310a617e94084df137ea0768acf8cTest
https://doi.org/10.1038/nature22313Test

المؤلفون: Yoon-A Kang, Aurélie Hérault, Eric M. Pietras, Mikhail Binnewies, Stephanie Leong, Scott A. Armstrong, Berthold Göttgens, Fernando J Calero-Nieto, Si Yi Zhang, S. Haihua Chu, Keegan Barry-Holson, Xiaonan Wang, Emmanuelle Passegué

المساهمون: Gottgens, Berthold [0000-0001-6302-5705], Apollo - University of Cambridge Repository

المصدر: Nature, vol 544, iss 7648

مصطلحات موضوعية: 0301 basic medicine, Myeloid, General Science & Technology, Granulocyte, Biology, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Granulocyte-Macrophage Progenitor Cells, Cell Self Renewal, medicine, Animals, Stem Cell Niche, beta Catenin, Progenitor, Myelopoiesis, Leukemia, Multidisciplinary, Macrophages, Cellular Reprogramming, Molecular Imaging, 3. Good health, Cell biology, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Interferon Regulatory Factors, Immunology, Neoplastic Stem Cells, Cytokines, Bone marrow, IRF8, Granulocytes

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6625174e70c4c5cb152cbe638e8def3Test
https://doi.org/10.1038/nature21693Test

المؤلفون: GuangJun Zhang, Davys H. Lopez, Martin J. Cohn, Oscar A. Tarazona, Leslie A. Slota

المصدر: Nature. 533:86-89

مصطلحات موضوعية: 0301 basic medicine, Fibrillar Collagens, Lophotrochozoa, Chondrocyte, Evolution, Molecular, 03 medical and health sciences, Chondrocytes, medicine, Animals, Gene Regulatory Networks, Hedgehog Proteins, Bilateria, Conserved Sequence, Phylogeny, beta Catenin, Multidisciplinary, Deuterostome, biology, Stem Cells, Cartilage, Decapodiformes, Gene Expression Regulation, Developmental, Anatomy, Chondrogenesis, biology.organism_classification, Invertebrates, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Vertebrates, Protostome, Ecdysozoa, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e720c7d2ca30de8a82ff33cacc27555Test
https://doi.org/10.1038/nature17398Test

المؤلفون: Rosemary C. Bagot, Erin S. Calipari, Michelle S. Mazei-Robison, Ezekiell Mouzon, Li Shen, Efrain Ribeiro, Carol A. Tamminga, Catherine Jensen Pena, HaoSheng Sun, Benoit Labonté, Rachael L. Neve, Xiaochuan Liu, Subroto Ghose, Jian Feng, Caroline Dias, Kimberly N. Scobie, Ning Y.i. Shao, Eric J. Nestler, Pamela J. Kennedy, Vincent Vialou, Ja W.ook Koo, Deveroux Ferguson, Diane M. Damez-Werno

المصدر: Nature. 516:51-55

مصطلحات موضوعية: Male, Ribonuclease III, Small RNA, Regulator, Molecular neuroscience, Biology, Nucleus accumbens, Medium spiny neuron, DEAD-box RNA Helicases, Mice, Stress, Physiological, microRNA, Animals, Humans, Chronic stress, beta Catenin, Neurons, Genetics, Regulation of gene expression, Multidisciplinary, Depression, Gene Expression Profiling, Resilience, Psychological, Adaptation, Physiological, Mice, Inbred C57BL, MicroRNAs, Gene Expression Regulation, Neuroscience, Genome-Wide Association Study, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c705239b6a7e1016e3b6b233ca7fb4f0Test
https://doi.org/10.1038/nature13976Test

المؤلفون: Phillip A. Sharp, Sidi Chen, Thales Papagiannakopoulos, Daniel G. Anderson, Denise G. Crowley, Tuomas Tammela, Gillian R. Yang, Hao Yin, Roderick T. Bronson, Wenxin Cai, Tyler Jacks, Wen-Bin Xue, Nikhil S. Joshi, Feng Zhang

المصدر: Nature. 514:380-384

مصطلحات موضوعية: Molecular Sequence Data, Mutagenesis (molecular biology technique), medicine.disease_cause, Mice, medicine, Animals, CRISPR, PTEN, Clustered Regularly Interspaced Short Palindromic Repeats, Genes, Tumor Suppressor, Phosphorylation, Gene, beta Catenin, Mutation, Multidisciplinary, Base Sequence, biology, Cas9, Point mutation, Liver Neoplasms, PTEN Phosphohydrolase, Gene targeting, Oncogenes, Genes, p53, Lipid Metabolism, Molecular biology, 3. Good health, Cell Transformation, Neoplastic, Liver, Mutagenesis, Hepatocytes, Cancer research, biology.protein, Female, CRISPR-Cas Systems, Genetic Engineering, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7083236a07c3098fbe8d12bbd96a54Test
https://doi.org/10.1038/nature13589Test

المؤلفون: Guy Brachya, Yinon Ben-Neriah, Irit Snir-Alkalay, Ela Elyada, Ido Burstain, Robert Goldstein, Gady Cojocaru, Eli Pikarsky, Zoltán Wiener, Steffen Jung, Rebecca Haffner-Krausz, Ariel Pribluda, Moshe Oren, Kari Alitalo, Yael Morgenstern

المصدر: Nature. 470:409-413

مصطلحات موضوعية: Male, Loss of Heterozygosity, medicine.disease_cause, Malignant transformation, Mice, 0302 clinical medicine, Intestinal mucosa, Genes, Tumor Suppressor, Intestinal Mucosa, Cellular Senescence, beta Catenin, Mice, Knockout, 0303 health sciences, Multidisciplinary, biology, Wnt signaling pathway, Casein Kinase Ialpha, Hedgehog signaling pathway, 3. Good health, Cell Transformation, Neoplastic, 030220 oncology & carcinogenesis, Disease Progression, Female, Signal transduction, Colorectal Neoplasms, Cell aging, Signal Transduction, Adenoma, Cyclin-Dependent Kinase Inhibitor p21, Genes, APC, Beta-catenin, Cell Line, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, Neoplasm Invasiveness, Cell Proliferation, 030304 developmental biology, Homeodomain Proteins, Tumor Suppressor Proteins, Fibroblasts, Wnt Proteins, Immunology, biology.protein, Cancer research, Tumor Suppressor Protein p53, Carcinogenesis, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94336d471cc20ffdfec092de4b2a4b2Test
https://doi.org/10.1038/nature09673Test

المؤلفون: Silvia J. H. Park, Bo Chen, Bhupesh Mehta, Xinran Liu, Ethan J. Mohns, Kai Yao, Michael C. Crair, Suo Qiu, Yanbin V. Wang, Bo Chang, Jonathan B. Demb, David Zenisek

المصدر: Nature. 560(7719)

مصطلحات موضوعية: 0301 basic medicine, Male, genetic structures, Neurogenesis, Population, Biology, Blindness, Regenerative Medicine, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Retinal Rod Photoreceptor Cells, medicine, Animals, Visual Pathways, Rod cell, Transducin, Progenitor cell, education, beta Catenin, Cell Proliferation, Visual Cortex, education.field_of_study, Retina, Multidisciplinary, Stem Cells, Cell Cycle, Retinal, Cellular Reprogramming, Heterotrimeric GTP-Binding Proteins, eye diseases, GTP-Binding Protein alpha Subunits, Cell biology, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, chemistry, Female, sense organs, Stem cell, Muller glia, Neuroglia, 030217 neurology & neurosurgery, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1b559adf5a3da4faf5f4ca192948adTest
https://pubmed.ncbi.nlm.nih.gov/30194409Test