دورية أكاديمية
l-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis
| العنوان: | l-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis |
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| المؤلفون: | Juan Yang, Lina Cha, Yepeng Wang, Quan Zhang, Xiaopeng Tang, Jianlin Shao, Zilei Duan |
| المصدر: | Natural Products and Bioprospecting, Vol 13, Iss 1, Pp 1-10 (2023) |
| بيانات النشر: | SpringerOpen, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Botany |
| مصطلحات موضوعية: | l-palmitoylcarnitine, Coagulation, Plasmin, Tissue-type plasminogen activator, Thrombosis, Botany, QK1-989 |
| الوصف: | Abstract l-Palmitoylcarnitine (L-PC) is an important endogenous fatty acid metabolite. Its classical biological functions are involved in the regulations of membrane molecular dynamics and the β-oxidation of fatty acids. Decreased plasma long-chain acylcarnitines showed the association of venous thrombosis, implying anticoagulant activity of the metabolites and inspiring us to investigate if and how L-PC, a long-chain acylcarnitine, takes part in coagulation. Here we show that L-PC exerted anti-coagulant effects by potentiating the enzymatic activities of plasmin and tissue plasminogen activator (tPA). L-PC directly interacts with plasmin and tPA with an equilibrium dissociation constant (KD) of 6.47 × 10–9 and 4.46 × 10–9 M, respectively, showing high affinities. In mouse model, L-PC administration significantly inhibited FeCl3-induced arterial thrombosis. It also mitigated intracerebral thrombosis and inflammation in a transient middle cerebral artery occlusion (tMCAO) mouse model. L-PC induced little bleeding complications. The results show that L-PC has anti-thrombotic function by potentiating plasmin and tPA. Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2192-2195 2192-2209 |
| العلاقة: | https://doaj.org/toc/2192-2195Test; https://doaj.org/toc/2192-2209Test |
| DOI: | 10.1007/s13659-023-00413-z |
| الوصول الحر: | https://doaj.org/article/2bf461df6c9e485687ff9d5004fb9043Test |
| رقم الانضمام: | edsdoj.2bf461df6c9e485687ff9d5004fb9043 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21922195 21922209 |
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| DOI: | 10.1007/s13659-023-00413-z |