Zinc Oxide Nanorods-Decorated Graphene Nanoplatelets: A Promising Antimicrobial Agent against the Cariogenic Bacterium Streptococcus mutans
| العنوان: | Zinc Oxide Nanorods-Decorated Graphene Nanoplatelets: A Promising Antimicrobial Agent against the Cariogenic Bacterium Streptococcus mutans |
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| المؤلفون: | Giovanna Armiento, Paolo Ballirano, Maria Sabrina Sarto, Daniela Uccelletti, Chandrakanth Reddy Chandraiahgari, Antonella Polimeni, Giovanni De Bellis, Maria Rita Montereali, Elena Zanni |
| المساهمون: | Armiento, G. |
| المصدر: | Nanomaterials, Vol 6, Iss 10, p 179 (2016) Nanomaterials; Volume 6; Issue 10; Pages: 179 Nanomaterials |
| بيانات النشر: | MDPI AG, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Materials science, General Chemical Engineering, Oxide, Streptococcus mutan, chemistry.chemical_element, 02 engineering and technology, Zinc, 010402 general chemistry, 01 natural sciences, Article, Microbiology, Nanomaterials, lcsh:Chemistry, chemistry.chemical_compound, antimicrobial activity, composite, dental caries, graphene nanoplatelets, Streptococcus mutans, zinc oxide, materials science (all), chemical engineering (all), Safranin, Dental carie, Antimicrobial activity, Composite, Dental caries, Graphene nanoplatelets, Zinc oxide, General Materials Science, Viability assay, biology, Biofilm, 021001 nanoscience & nanotechnology, Antimicrobial, biology.organism_classification, streptococcus mutans, 0104 chemical sciences, Graphene nanoplatelet, lcsh:QD1-999, chemistry, 0210 nano-technology, Nuclear chemistry |
| الوصف: | Nanomaterials are revolutionizing the field of medicine to improve the quality of life due to the myriad of applications stemming from their unique properties,including the antimicrobial activity against pathogens. In this study,the antimicrobial and antibiofilm properties of a novel nanomaterial composed by zinc oxide nanorods-decorated graphene nanoplatelets (ZNGs) are investigated. ZNGs were produced by hydrothermal method and characterized through field-emission scanning electron microscopy (FE-SEM),energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD) techniques. The antimicrobial activity of ZNGs was evaluated against Streptococcus mutans,the main bacteriological agent in the etiology of dental caries. Cell viability assay demonstrated that ZNGs exerted a strikingly high killing effect on S. mutans cells in a dose-dependent manner. Moreover,FE-SEM analysis revealed relevant mechanical damages exerted by ZNGs at the cell surface of this dental pathogen rather than reactive oxygen species (ROS) generation. In addition,inductively coupled plasma mass spectrometry (ICP-MS) measurements showed negligible zinc dissolution,demonstrating that zinc ion release in the suspension is not associated with the high cellmortality rate. Finally,our data indicated that also S. mutans biofilm formation was affected by thepresence of graphene-zinc oxide (ZnO) based material,as witnessed by the safranin staining andgrowth curve analysis. Therefore,ZNGs can be a remarkable nanobactericide against one of the maindental pathogens. The potential applications in dental care and therapy are very promising. © 2016 by the authors; licensee MDPI,Basel,Switzerland. |
| وصف الملف: | application/pdf |
| تدمد: | 2079-4991 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49a47a16b2847508ffee2499ffee648Test https://doi.org/10.3390/nano6100179Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d49a47a16b2847508ffee2499ffee648 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20794991 |
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