Telomere shortening and aortic plaque progression in Apoliprotein E knockout mice after pulmonary exposure to candle light combustion particles
| العنوان: | Telomere shortening and aortic plaque progression in Apoliprotein E knockout mice after pulmonary exposure to candle light combustion particles |
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| المؤلفون: | Martin Roursgaard, Peter Møller, Annie Aarup Jensen, Steffen Loft, Astrid Skovman, Ana Cecilia Damiao Gouveia, Ismo K. Koponen |
| المصدر: | Mutagenesis. 33:253-261 |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Apolipoprotein E, medicine.medical_specialty, Health, Toxicology and Mutagenesis, Inflammation, 010501 environmental sciences, Toxicology, 01 natural sciences, Mice, 03 medical and health sciences, chemistry.chemical_compound, Apolipoproteins E, Internal medicine, Lactate dehydrogenase, Genetics, medicine, Animals, Humans, Particle Size, Lung, Cell damage, Aorta, Telomere Shortening, Genetics (clinical), 0105 earth and related environmental sciences, Mice, Knockout, chemistry.chemical_classification, Air Pollutants, Reactive oxygen species, medicine.diagnostic_test, Atherosclerosis, medicine.disease, Plaque, Atherosclerotic, Oxidative Stress, 030104 developmental biology, Bronchoalveolar lavage, Endocrinology, medicine.anatomical_structure, chemistry, Knockout mouse, Particulate Matter, medicine.symptom, Reactive Oxygen Species |
| الوصف: | Particles from burning candles contribute to the overall indoor exposure to particulate matter (PM). However, little is known about the effects of indoor sources of particles on cardiovascular disease endpoints. This study investigated the effect of pulmonary exposure to particles from combustion of candles and progression of atherosclerosis. Telomere shortening was assessed in tissues due to its relationship to risk of cardiovascular diseases. The particles were collected from burning candles and used for toxicological studies in cultured endothelial cells and apolipoprotein E (ApoE) knockout mice. Three hours exposure to particles increased the production of reactive oxygen species in endothelial cells, whereas there was no effect on cytotoxicity. Intratracheal instillation of particles (0.5 or 5 mg/kg) once a week for 5 weeks in ApoE-/- mice was associated with an accelerated progression of atherosclerosis in aorta and telomere shortening in the lung and spleen, whereas there was no effect on inflammation in the lungs (i.e. cell numbers), cell damage (i.e. lactate dehydrogenase) and lung barrier damage (i.e. protein concentration) as measured in bronchoalveolar lavage fluid. The results indicate that particles from burning candles are hazardous and this indoor emission source is an important contribution to the health risk of exposure to PM. |
| تدمد: | 1464-3804 0267-8357 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f851c0cfb9a180020b553fd972994d5bTest https://doi.org/10.1093/mutage/gey015Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f851c0cfb9a180020b553fd972994d5b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14643804 02678357 |
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