Axonal transport of choline acetyltransferase and 6-phosphofructokinase activities in genetically diabetic mice
| العنوان: | Axonal transport of choline acetyltransferase and 6-phosphofructokinase activities in genetically diabetic mice |
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| المؤلفون: | D. R. Tomlinson, Nigel A. Calcutt, G.B. Willars |
| المصدر: | Muscle & Nerve. 11:1206-1210 |
| بيانات النشر: | Wiley, 1988. |
| سنة النشر: | 1988 |
| مصطلحات موضوعية: | medicine.medical_specialty, Physiology, Phosphofructokinase-1, Fructose, Biology, Axonal Transport, Choline O-Acetyltransferase, Diabetes Mellitus, Experimental, Mice, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Physiology (medical), Internal medicine, Diabetes mellitus, medicine, Animals, Sorbitol, Axon, medicine.disease, Choline acetyltransferase, Anterograde axonal transport, Mice, Inbred C57BL, Endocrinology, medicine.anatomical_structure, chemistry, Axoplasmic transport, Female, Neurology (clinical), Inositol, Phosphofructokinase |
| الوصف: | This study examined the anterograde axonal transport of activities of the cytoplasmic enzymes choline acetyltransferase and 6-phosphofructokinase in genetically diabetic C57BL/Ks (db/db) mice and their nondiabetic (+/?) littermates. Diabetic mice exhibited marked reductions in the accumulation of both choline acetyltransferase and 6-phosphofructokinase activity against a constriction of the left sciatic nerve (38% and 51% of nondiabetic values, respectively). Enzyme activities per unit length of unconstricted nerve were not different from those of nondiabetic mice. The nerves of diabetic mice did not accumulate measurable amounts of sorbitol or fructose and showed no myo-inositol depletion. Thus this study concludes that, in diabetic mice, the deficits in anterograde axonal transport of these two enzymes do not arise from the accumulation of sorbitol and fructose nor from depletion of nerve free myo-inositol. |
| تدمد: | 1097-4598 0148-639X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353648886c0d8e28b48a6d4c34c5d84dTest https://doi.org/10.1002/mus.880111204Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....353648886c0d8e28b48a6d4c34c5d84d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974598 0148639X |
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