Colchicine alters apamin receptors, electrical activity, and skeletal muscle relaxation
| العنوان: | Colchicine alters apamin receptors, electrical activity, and skeletal muscle relaxation |
|---|---|
| المؤلفون: | Maria I. Behrens, Cecilia Vergara, Beatriz U. Ramirez |
| المصدر: | Muscle & Nerve. 16:935-940 |
| بيانات النشر: | Wiley, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Potassium Channels, Physiology, Muscle Relaxation, Electromyography, Biology, Apamin, Axonal Transport, complex mixtures, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Physiology (medical), Internal medicine, medicine, Animals, Colchicine, Relaxation (psychology), medicine.diagnostic_test, Muscles, musculoskeletal, neural, and ocular physiology, Skeletal muscle, Biological activity, musculoskeletal system, Myotonia, medicine.disease, Sciatic Nerve, Muscle Denervation, Rats, Receptors, Neurotransmitter, Electrophysiology, Endocrinology, Muscle relaxation, medicine.anatomical_structure, chemistry, Neurology (clinical) |
| الوصف: | A low conductance calcium-activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that axonal flow blockade of rat nerves, induced by colchicine, caused atransient increase in muscle apamin receptors, determined by 125I-apamin binding to membrane fractions. The increase in apamin receptors was correlated with repetitive discharges resembling myotonic potentials in the electromyogram, that were blockable by apamin. Here we show that the increase in muscle apamin receptors and the alteration of the electromyogram are followed closely by a slowing of the twitch relaxation, that in turn, is decreased by apamin. Furthermore, the presence of myotonic-like alterations in the electromyogram and a slowing of muscle relaxation when muscle apaminreceptors are increased suggests that these channels may participate, amongother factors, in the generation of some kinds of myotonia. © 1993 John Wiley & Sons, Inc. |
| تدمد: | 1097-4598 0148-639X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957e0ee4f6f76f887c83a34ae451c4f4Test https://doi.org/10.1002/mus.880160908Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....957e0ee4f6f76f887c83a34ae451c4f4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974598 0148639X |
|---|