التفاصيل البيبلوغرافية
| العنوان: |
Primary progressive versus relapsing-onset multiple sclerosis: presence and prognostic value of cerebrospinal fluid oligoclonal IgM. |
| المؤلفون: |
Sola, Patrizia, Mandrioli, Jessica, Simone, Anna M., Ferraro, Diana, Bedin, Roberta, Annecca, Rosanna, Venneri, Maria G., Nichelli, Paolo F., Merelli, Elisa |
| المصدر: |
Multiple Sclerosis Journal; 03/01/2011, Vol. 17 Issue 3, p303-311, 9p, 4 Charts, 2 Graphs |
| مصطلحات موضوعية: |
CEREBROSPINAL fluid, MULTIPLE sclerosis, PROGNOSIS, DISEASE relapse, PATHOGENIC microorganisms, DISABILITIES |
| مستخلص: |
Background: There is increasing evidence on cerebrospinal fluid (CSF) oligoclonal IgM (OCIgM) predicting a more aggressive disease course in relapsing—remitting Multiple Sclerosis (MS), while there is a scarcity of data for primary progressive MS (PPMS).Objective: Our aim was to investigate the presence and possible prognostic value of CSF OCIgM in a group of PPMS and in a group of relapsing-onset MS patients. The possible prognostic role of other clinical and biological factors was also evaluated.Methods: We calculated the impact of single clinical and biological factors, including CSF OCIgM at onset, on the probability of reaching an Expanded Disability Status Scale of 3 and 4 in 45 PPMS and 104 relapsing-onset MS patients.Results: CSF OCIgM were found in only 13% of PPMS patients and did not influence the time taken to reach an Expanded Disability Status Scale of 3 and 4. Conversely, they were present in 46% of relapsing-onset MS patients and increased the risk of reaching an Expanded Disability Status Scale of 4. Clinical factors with a negative prognostic value in PPMS were age at onset <30 years and onset with pyramidal symptoms, while onset with sensory symptoms in relapsing-onset MS predicted a more favourable course.Conclusion: This study confirms that, in relapsing-onset MS patients, the presence of CSF OCIgM at onset predicts a worse disease course. In the cohort of PPMS patients, however, CSF OCIgM were rare, suggesting that heterogeneous pathogenetic mechanisms may be involved in the different MS forms. [ABSTRACT FROM PUBLISHER] |
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| قاعدة البيانات: |
Complementary Index |
