Myelin imaging measures as predictors of cognitive impairment in MS patients: A hybrid PET-MRI study

التفاصيل البيبلوغرافية
العنوان: Myelin imaging measures as predictors of cognitive impairment in MS patients: A hybrid PET-MRI study
المؤلفون: Campanholo, KR, Pitombeira, MS, Rimkus, CM, Mendes, MF, Apóstolos-Pereira, SL, Busatto Filho, G, Callegaro, D, Buchpiguel, CA, Duran, FLS, De Paula Faria, D
المصدر: Multiple Sclerosis and Related Disorders; January 2022, Vol. 57 Issue: 1
مستخلص: •Different imaging techniques (DTI, MTR and 11C-PIB PET) were compared.•All images from one subject were acquired simultaneously in a PET/MR hybrid system.•Low MTR in thalamus and corpus callosum were predictors of cognitive impairment in the entire MS cohort.•DTI showed association in PMS, while MTR and 11C-PIB uptake (DVR) in RRMS.•11C-PIB PET was a method more consistently associated with cognitive parameters.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:22110348
DOI:10.1016/j.msard.2021.103331