Striatal spreading depolarization: Possible implication in levodopa‐induced dyskinetic‐like behavior
| العنوان: | Striatal spreading depolarization: Possible implication in levodopa‐induced dyskinetic‐like behavior |
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| المؤلفون: | Cinzia Costa, Michela Tantucci, Petra Mazzocchetti, Alessandro Tozzi, Antonio de Iure, Daniela Punzo, Goichi Beck, Veronica Ghiglieri, Ana Quiroga Varela, Antonella Cardinale, Miriam Sciaccaluga, Francesco Napolitano, Alessandro Usiello, Stella M. Papa, Paolo Calabresi, Valentina Durante, Andrea Mancini, Barbara Picconi, Alfredo Megaro |
| المساهمون: | de Iure, A, Napolitano, F, Beck, G, Quiroga Varela, A, Durante, V, Sciaccaluga, M, Mazzocchetti, P, Megaro, A, Tantucci, M, Cardinale, A, Punzo, D, Mancini, A, Costa, C, Ghiglieri, V, Tozzi, A, Picconi, B, Papa, Sm, Usiello, A, Calabresi, P, de Iure, Antonio, Napolitano, Francesco, Beck, Goichi, Quiroga Varela, Ana, Durante, Valentina, Sciaccaluga, Miriam, Mazzocchetti, Petra, Megaro, Alfredo, Tantucci, Michela, Cardinale, Antonella, Punzo, Daniela, Mancini, Andrea, Costa, Cinzia, Ghiglieri, Veronica, Tozzi, Alessandro, Picconi, Barbara, Papa, Stella M., Usiello, Alessandro, Calabresi, Paolo |
| المصدر: | Mov Disord |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | LIDs, 0301 basic medicine, Dyskinesia, Drug-Induced, Spreading depolarization, Parkinson's disease, Prednisolone, Wistar, D1-like receptor, Striatum, Neurotransmission, D1 like receptor, Animals, Antineoplastic Combined Chemotherapy Protocols, Antiparkinson Agents, Corpus Striatum, Dopaminergic Neurons, Levodopa, Neurons, Nitrogen Mustard Compounds, Parkinsonian Disorders, Procarbazine, Rats, Rats, Wistar, Synaptic Transmission, Vincristine, Neurology, Neurology (clinical), Article, 03 medical and health sciences, 0302 clinical medicine, Basal ganglia, medicine, Premovement neuronal activity, LID, Dyskinesia, Chemistry, Dopaminergic, Depolarization, medicine.disease, Settore MED/26 - NEUROLOGIA, 030104 developmental biology, nervous system, Drug-Induced, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Objective Spreading depolarization (SD) is a transient self-propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the cortex is implicated in migraine, stroke, and epilepsy. Conversely, spreading depolarization in the striatum, a brain structure deeply involved in motor control and in Parkinson's disease (PD) pathophysiology, has been poorly investigated. Methods We characterized the participation of glutamatergic and dopaminergic transmission in the induction of striatal spreading depolarization by using a novel approach combining optical imaging, measurements of endogenous DA levels, and pharmacological and molecular analyses. Results We found that striatal spreading depolarization requires the concomitant activation of D1-like DA and N-methyl-d-aspartate receptors, and it is reduced in experimental PD. Chronic l-dopa treatment, inducing dyskinesia in the parkinsonian condition, increases the occurrence and speed of propagation of striatal spreading depolarization, which has a direct impact on one of the signaling pathways downstream from the activation of D1 receptors. Conclusion Striatal spreading depolarization might contribute to abnormal basal ganglia activity in the dyskinetic condition and represents a possible therapeutic target. © 2019 International Parkinson and Movement Disorder Society. |
| تدمد: | 1531-8257 0885-3185 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef2776848e5c32a182e86b8a3f5de31Test https://doi.org/10.1002/mds.27632Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8ef2776848e5c32a182e86b8a3f5de31 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15318257 08853185 |
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