Axonal excitability properties in hemifacial spasm
| العنوان: | Axonal excitability properties in hemifacial spasm |
|---|---|
| المؤلفون: | Arun V. Krishnan, Matthew C. Kiernan, Michael Hayes |
| المصدر: | Movement Disorders. 22:1293-1298 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, Neural Conduction, Stimulation, Reaction Time, medicine, Humans, Hemifacial Spasm, Axon, Aged, Membrane potential, Depolarization, Anatomy, Middle Aged, medicine.disease, Control subjects, Facial nerve, Axons, Electric Stimulation, Facial Nerve, medicine.anatomical_structure, Neurology, Female, Neurology (clinical), Psychology, Neuroscience, Hemifacial spasm, Nerve excitability |
| الوصف: | Hemifacial spasm (HFS) is characterized by involuntary, irregular contractions of muscles innervated by the facial nerve. Whether the facial nerve has a relative predisposition for ectopic activity has not been clarified. Nerve excitability techniques, which provide information about membrane potential and axonal ion channel function, were initially measured in 12 control subjects looking for biophysical differences that may predispose the facial nerve to generate ectopic activity. In a second series of studies, facial nerve excitability was assessed in nine HFS patients. In both series, stimulus-response behavior, threshold electrotonus, a current threshold relationship, and the recovery of excitability following supramaximal stimulation were recorded following stimulation of the facial nerve. When compared to normative data from nerves in the upper and lower limbs, there was a relative "fanning-in" of threshold electrotonus, reduced superexcitability, and increased subexcitability in facial nerve studies from control subjects (P < 0.05), consistent with relative axonal depolarization. These findings may underlie the propensity for the facial nerve to develop ectopic impulse activity in motor axons. In the HFS patient study, there were no significant differences in distal facial nerve excitability properties from the affected side in HFS patients when compared either to the unaffected side or to normative facial nerve data. It is concluded that the impulse generator underlying HFS must consequently be sited more proximally and does not cause a generalized disturbance of motor axon excitability. |
| تدمد: | 1531-8257 0885-3185 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab256724b79762d3bc44f83b4ed68ff9Test https://doi.org/10.1002/mds.21512Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ab256724b79762d3bc44f83b4ed68ff9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15318257 08853185 |
|---|