دورية أكاديمية
Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link
العنوان: | Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link |
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المؤلفون: | Naji Kholaif, Lin Batha, Isra Elmahi, Sulaiman Alnaser, Sultan Alzaher, Norah Almallohi, Mosaad Alhussein, Dana Alhalees, Ahmed Alshehri |
المصدر: | Monaldi Archives for Chest Disease (2024) |
بيانات النشر: | PAGEPress Publications, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Medicine |
مصطلحات موضوعية: | Living donor liver transplant, familial hypercholesterolemia, non-alcoholic steatohepatitis, myocardial infraction, Medicine |
الوصف: | Living donor liver transplantation (LDLT) is a lifesaving procedure that is often curative for several liver diseases. Familial hypercholesterolemia (FH) is a metabolic disease that results from an autosomal dominant mutation in the low-density lipoprotein receptor; yet, young patients with FH can live years without detection. Herein, we report a case of a patient who developed early myocardial infarction (MI) after having a transplant from a donor with undetected heterozygous FH. This was a 67-year-old female with non-alcoholic steatohepatitis-related liver cirrhosis, free from coronary artery disease, who underwent LDLT from her daughter, a 45-year-old female with no past medical history. One year post-transplant, she presented with an acute MI with a large atherosclerotic burden. Genetic analysis confirmed heterozygous FH in the donor but not in the recipient. This case emphasizes the importance of incorporating a thorough clinical history and lipid profile into pre-transplant testing for both the recipient and donor, as well as aggressive lipid-lowering therapy post-transplantation to avoid cardiovascular complications. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1122-0643 2532-5264 |
العلاقة: | https://www.monaldi-archives.org/index.php/macd/article/view/2907Test; https://doaj.org/toc/1122-0643Test; https://doaj.org/toc/2532-5264Test |
DOI: | 10.4081/monaldi.2024.2907 |
الوصول الحر: | https://doaj.org/article/3a4465d6615541e496f0f78d7058738eTest |
رقم الانضمام: | edsdoj.3a4465d6615541e496f0f78d7058738e |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 11220643 25325264 |
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DOI: | 10.4081/monaldi.2024.2907 |