التفاصيل البيبلوغرافية
| العنوان: |
Biocatalytic Synthesis of Novel Partial Esters of a Bioactive Dihydroxy 4-Methylcoumarin by Rhizopus oryzae Lipase (ROL). |
| المؤلفون: |
Kumar, Vinod, Mathur, Divya, Srivastava, Smriti, Malhotra, Shashwat, Rana, Neha, Singh, Suraj K., Singh, Brajendra K., Prasad, Ashok K., Varma, Anjani J., Len, Christophe, Kuhad, Ramesh C., Saxena, Rajendra K., Parmar, Virinder S. |
| المصدر: |
Molecules; Nov2016, Vol. 21 Issue 11, p1499, 11p, 3 Diagrams, 1 Chart, 1 Graph |
| مستخلص: |
Highly regioselective acylation has been observed in 7,8-dihydroxy-4-methylcoumarin (DHMC) by the lipase from Rhizopus oryzae suspended in tetrahydrofuran (THF) at 45 °C using six different acid anhydrides as acylating agents. The acylation occurred regioselectively at one of the two hydroxy groups of the coumarin moiety resulting in the formation of 8-acyloxy-7-hydroxy-4-methylcoumarins, which are important bioactive molecules for studying biotansformations in animals, and are otherwise very difficult to obtain by only chemical steps. Six monoacylated, monohydroxy 4-methylcoumarins have been biocatalytically synthesised and identified on the basis of their spectral data and X-ray crystal analysis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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