Synthesis and Biological Evaluation of Some New Coumarin Derivatives
| العنوان: | Synthesis and Biological Evaluation of Some New Coumarin Derivatives |
|---|---|
| المؤلفون: | M. A. Al-Haiza, M. Y. El-Kady, Mohamed S. Mostafa |
| المصدر: | Molecules, Vol 8, Iss 2, Pp 275-286 (2003) Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules; Volume 8; Issue 2; Pages: 275-286 |
| بيانات النشر: | MDPI AG, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Stereochemistry, 2-c][1]benzopyran, pyrimidino[5`, Pharmaceutical Science, Pyrano[3,2-c][1]benzopyran, Alkylation, Chloroacetyl chloride, Chloride, Article, Analytical Chemistry, pyrrolo[3`,2`-5,6]4H-pyrano[3,2-c][1]benzopyran-6-one, lcsh:QD241-441, chemistry.chemical_compound, pyrimidino[5`,4`-6,5], lcsh:Organic chemistry, Drug Discovery, medicine, Moiety, 5], pyrrolo[3`, antimicrobial activities, Physical and Theoretical Chemistry, Pyrano[3, 4`-6, 2`-5, 6]4Hpyrano[ 3, 2-c][1]benzopyran-6-one, Biological evaluation, Chemistry, Organic Chemistry, Coumarin, Benzopyran, Chemistry (miscellaneous), Molecular Medicine, medicine.drug |
| الوصف: | Pyrimidino[5`,4`-6,5]-,pyridino[3`,2`-6,5]- and pyrrolo[3`,2`-5,6]4H-pyrano-[3,2-c][1]benzopyran-6-one derivatives ( 5-7 and 10 ) could be obtained via reaction of 2-amino-4-( p -bromophenyl)-3-cyano(carboethoxy)-4H,5H-pyrano[3,2-c][1]benzopyran-5-ones ( 3a,b ) with a variety of reagents. Alkylation of( 3b ) with either 2-furoyl chloride or chloroacetyl chloride gave the 2- N -substituted derivatives ( 9a,b ). Benzofurano[3,2-b]4H-pyran derivative (12 ) was also prepared. The antimicrobial activity of the prepared compounds was tested. Keywords Pyrano[3,2: -c][1]benzopyran ; pyrimidino[5`,4`-6,5]-; pyrrolo[3`,2`-5,6]4H-pyrano[3,2-c][1]benzopyran-6-one; antimicrobial activities. Introduction Coumarins are nowadays an important group of organic compounds that are used as bactericides [1-3], fungicides [4], anti-inflammatory [5], anticoagulant [6] and antitumour agents [7,8]. These pharmacological properties of coumarins aroused our interest in synthesizing several new compounds featuring different heterocyclic rings fused onto the coumarin moiety with the aim of obtaining more potent pharmacologically active compounds. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510adac4bdb97f2af98343b4661c2bd8Test http://www.mdpi.com/1420-3049/8/2/275Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....510adac4bdb97f2af98343b4661c2bd8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
|---|