دورية أكاديمية
Antioxidant Extracts of Three Russula Genus Species Express Diverse Biological Activity
| العنوان: | Antioxidant Extracts of Three Russula Genus Species Express Diverse Biological Activity |
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| المؤلفون: | Kostić, Marina, Ivanov, Marija, Fernandes, Ângela, Pinela, José, Calhelha, Ricardo C., Glamočlija, Jasmina, Barros, Lillian, Ferreira, Isabel C. F. R., Soković, Marina, Ćirić, Ana |
| المصدر: | Molecules |
| بيانات النشر: | NLM (Medline) |
| سنة النشر: | 2020 |
| المجموعة: | RADaR - Digital Repository of Archived Publications Institute for Biological Research "Sinisa Stankovic" / РАДаР - Репозиторијум Архивираних Дигиталних Радова Институт за биолошка истраживања "Синиша Станковић" |
| مصطلحات موضوعية: | Russula integra, Russula nigricans, Russula rosea, Antibacterial agents, Antibiofilm activity, Antioxidant activity, Cytotoxicity, Functional ingredients |
| الوصف: | This study explored the biological properties of three wild growing Russula species (R. integra, R. rosea, R. nigricans) from Serbia. Compositional features and antioxidant, antibacterial, antibiofilm, and cytotoxic activities were analyzed. The studied mushroom species were identified as being rich sources of carbohydrates and of low caloric value. Mannitol was the most abundant free sugar and quinic and malic acids the major organic acids detected. The four tocopherol isoforms were found, and polyunsaturated fatty acids were the predominant fat constituents. Regarding phenolic compounds, P-hydroxybenzoic and cinnamic acids were identified in the prepared methanolic and ethanolic extracts, which displayed antioxidant activity through the inhibition of thiobarbituric acid reactive substances (TBARS) formation and oxidative hemolysis; the highest activity was attributed to the R. nigricans ethanolic extract. This is the first report on the antibacterial and antibiofilm potential of the studied species, with the most promising activity observed towards Streptococcus spp. (0.20–0.78 mg/mL as the minimal inhibitory concentration, MIC). The most promising cytotoxic effect was caused by the R. integra methanolic extract on non-small cell lung cancer cells (NCI-H460). Therefore, due to the observed in vitro bioactive properties, the studied mushrooms arise as a source of functional ingredients with potential to be used in novel nutraceutical and drug formulations, which can be used in the treatment of various diseases and health conditions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| ردمك: | 978-0-00-582032-2 0-00-582032-4 |
| تدمد: | 1420-3049 |
| العلاقة: | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS//; Foundation for Science and Technology (FCT, Portugal); 0377_Iberphenol_6_E; https://www.mdpi.com/1420-3049/25/18/4336Test; https://radar.ibiss.bg.ac.rs/123456789/3905Test; 2-s2.0-85091617807; 000582032400001; https://radar.ibiss.bg.ac.rs/bitstream/id/7409/molecules-25-04336.pdfTest |
| DOI: | 10.3390/molecules25184336 |
| الإتاحة: | https://doi.org/10.3390/molecules25184336Test https://www.mdpi.com/1420-3049/25/18/4336Test https://radar.ibiss.bg.ac.rs/123456789/3905Test https://radar.ibiss.bg.ac.rs/bitstream/id/7409/molecules-25-04336.pdfTest |
| حقوق: | openAccess ; https://creativecommons.org/licenses/by/4.0Test/ ; BY ; © 2020 by the authors |
| رقم الانضمام: | edsbas.130A49AF |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9780005820322 0005820324 |
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| تدمد: | 14203049 |
| DOI: | 10.3390/molecules25184336 |