التفاصيل البيبلوغرافية
| العنوان: |
Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior. |
| المؤلفون: |
Wakschlag, L. S., Kistner, E. O., Pine, D. S., Biesecker, G., Pickett, K. E., Skol, A. D., Dukic, V., Blair, R. J. R., Leventhal, B. L., Cox, N. J., Burns, J. L., Kasza, K. E., Wright, R. J., Cook, E. H. |
| المصدر: |
Molecular Psychiatry; Sep2010, Vol. 15 Issue 9, p928-937, 10p, 1 Diagram, 4 Charts, 1 Graph |
| مصطلحات موضوعية: |
GENETIC research, DELINQUENT behavior, PRENATAL influences, CIGARETTE smoke, GENETIC polymorphisms, MONOAMINE oxidase |
| مستخلص: |
Genetic susceptibility to antisocial behavior may increase fetal sensitivity to prenatal exposure to cigarette smoke. Testing putative gene × exposure mechanisms requires precise measurement of exposure and outcomes. We tested whether a functional polymorphism in the gene encoding the enzyme monoamine oxidase A (MAOA) interacts with exposure to predict pathways to adolescent antisocial behavior. We assessed both clinical and information-processing outcomes. One hundred seventy-six adolescents and their mothers participated in a follow-up of a pregnancy cohort with well-characterized exposure. A sex-specific pattern of gene × exposure interaction was detected. Exposed boys with the low-activity MAOA 5′ uVNTR (untranslated region variable number of tandem repeats) genotype were at increased risk for conduct disorder (CD) symptoms. In contrast, exposed girls with the high-activity MAOA uVNTR genotype were at increased risk for both CD symptoms and hostile attribution bias on a face-processing task. There was no evidence of a gene–environment correlation (rGE). Findings suggest that the MAOA uVNTR genotype, prenatal exposure to cigarettes and sex interact to predict antisocial behavior and related information-processing patterns. Future research to replicate and extend these findings should focus on elucidating how gene × exposure interactions may shape behavior through associated changes in brain function. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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