التفاصيل البيبلوغرافية
| العنوان: |
First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. |
| المؤلفون: |
Roeske, D., Ludwig, K. U., Neuhoff, N., Becker, J., Bartling, J., Bruder, J., Brockschmidt, F. F., Warnke, A., Remschmidt, H., Hoffmann, P., Müller-Myhsok, B., Nöthen, M. M., Schulte-Körne, G. |
| المصدر: |
Molecular Psychiatry; Jan2011, Vol. 16 Issue 1, p97-107, 11p, 2 Charts, 2 Graphs |
| مصطلحات موضوعية: |
CHILDREN with dyslexia, MESSENGER RNA, SPEECH disorders, GENETIC polymorphisms, NEURONS |
| مستخلص: |
Dyslexia is one of the most common learning disorders affecting about 5% of all school-aged children. It has been shown that event-related potential measurements reveal differences between dyslexic children and age-matched controls. This holds particularly true for mismatch negativity (MMN), which reflects automatic speech deviance processing and is altered in dyslexic children. We performed a whole-genome association analysis in 200 dyslexic children, focusing on MMN measurements. We identified rs4234898, a marker located on chromosome 4q32.1, to be significantly associated with the late MMN component. This association could be replicated in an independent second sample of 186 dyslexic children, reaching genome-wide significance in the combined sample (P=5.14e−08). We also found an association between the late MMN component and a two-marker haplotype of rs4234898 and rs11100040, one of its neighboring single nucleotide polymorphisms (SNPs). In the combined sample, this marker combination withstands correction for multiple testing (P=6.71e−08). Both SNPs lie in a region devoid of any protein-coding genes; however, they both show significant association with mRNA-expression levels of SLC2A3 on chromosome 12, the predominant facilitative glucose transporter in neurons. Our results suggest a possible trans-regulation effect on SLC2A3, which might lead to glucose deficits in dyslexic children and could explain their attenuated MMN in passive listening tasks. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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