The Putative Caloric Restriction Mimetic Resveratrol has Moderate Impact on Insulin Sensitivity, Body Composition, and the Metabolome in Mice
| العنوان: | The Putative Caloric Restriction Mimetic Resveratrol has Moderate Impact on Insulin Sensitivity, Body Composition, and the Metabolome in Mice |
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| المؤلفون: | Sebastian T. Soukup, Marc Birringer, Gerald Rimbach, Nicolas Danylec, C.I. Mack, Kai Lüersen, Franz Bracher, Christoph H. Weinert, Ilka Günther, Sabine E. Kulling, Kathrin Pallauf |
| المصدر: | Molecular Nutrition & Food Research. 64:1901116 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Leptin, Male, 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Adipose tissue, Resveratrol, 03 medical and health sciences, chemistry.chemical_compound, Phenols, Internal medicine, Bibenzyls, Stilbenes, medicine, Metabolome, Animals, Insulin, Glycoside Hydrolase Inhibitors, Caloric restriction mimetic, Caloric Restriction, 030109 nutrition & dietetics, Glucose Tolerance Test, In vitro, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Liver, chemistry, Dietary Supplements, Body Composition, Insulin Resistance, Food Science, Biotechnology, Hormone |
| الوصف: | Scope Data on resveratrol-(trans-3,5,4'-trihydroxystilbene)-induced caloric-restriction-(CR)-mimicking effects in mice receiving a high-fat diet (HFD) are contradictory. It is hypothesized that this can possibly stem from different bioactivities of resveratrol (RSV) microbial metabolites. Methods and results C57BL/6Rj mice are fed an ad-libitum HFD supplemented with RSV or its metabolites, dihydroresveratrol (DHR) and lunularin (LUN) (≈28 mg (dihydro)stilbene kg-1 mouse per day). A 40% CR group was included in the study. While CR mice show robust changes in bodyweight and composition, hormone levels and mRNA expression, slight changes are found (more muscle, less adipose tissue) in body composition, leptin, and insulin levels in RSV-supplemented mice compared to ad libitum controls. LUN hardly and DHR does not change the hormone levels measured. Metabolome analysis of serum shows changes in CR mice but only slight, if any, changes in RSV-, DHR-, or LUN-supplemented mice compared to the controls. Evaluating the capability of RSV and its metabolites to inhibit carbohydrate-hydrolyzing enzymes in vitro, it is found that RSV reduced α-glucosidase activity to a stronger extent than DHR and LUN. Conclusion Decelerated carbohydrate breakdown by RSV may have contributed to the moderate impact of dietary RSV on mouse insulin sensitivity (lowered fasting and post-glucose-bolus insulin levels). |
| تدمد: | 1613-4133 1613-4125 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f34fdf0837a46184dd6eafda76b0eeTest https://doi.org/10.1002/mnfr.201901116Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....83f34fdf0837a46184dd6eafda76b0ee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16134133 16134125 |
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