E3�ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1
| العنوان: | E3�ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1 |
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| المؤلفون: | Xia Li, Yingxian Sun, Naijin Zhang, Shaojun Wu, Yichen Tian, Shilong You, Yuxuan Guo, Pengyu Jia, Ying Zhang |
| المصدر: | Molecular Medicine Reports |
| بيانات النشر: | Spandidos Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | F-box and WD repeat domain containing 7, 0301 basic medicine, Cancer Research, F-Box-WD Repeat-Containing Protein 7, Cell, Apoptosis, medicine.disease_cause, Biochemistry, MCL1 apoptosis regulator, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, Animals, Myocytes, Cardiac, RNA, Small Interfering, Molecular Biology, bcl-2-Associated X Protein, chemistry.chemical_classification, Reactive oxygen species, biology, Chemistry, Apoptosis Regulator, Hydrogen Peroxide, Articles, Cell cycle, BCL2 family member, Rats, Ubiquitin ligase, Cell biology, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Oncology, Bax, 030220 oncology & carcinogenesis, myocardial cell injury, biology.protein, Myeloid Cell Leukemia Sequence 1 Protein, Molecular Medicine, Signal transduction, Oxidative stress, Signal Transduction |
| الوصف: | Oxidative stress participates in several heart diseases and is an important mechanism contributing to the pathological alterations of myocardial cell injury. In recent years, ubiquitylation has been demonstrated to be an important biochemical reaction associated with apoptosis. To investigate the effects and interactions of the E3 ligase F-box and WD repeat domain containing 7 (Fbw7) and MCL1 apoptosis regulator, BCL2 family member (Mcl-1) in myocardial cells during oxidative stress, Cell Counting Kit-8, flow cytometry, western blot, reactive oxygen species and co-immunoprecipitation assays were conducted. The current study revealed that Fbw7 may facilitate apoptosis via the Mcl-1-Bax pathway in oxidative stress-induced myocardial H9c2 cell injury. Mcl-1 inhibits the functions of Bcl-2 family members, including the mitochondrial apoptosis factor Bax, to maintain cell viability; however, the present study suggested that Fbw7 may degrade Mcl-1 and impaired this process. Therefore, it may be hypothesized that Fbw-7 promotes myocardial cell injury via interacting with Mcl-1. |
| تدمد: | 1791-3004 1791-2997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df898e9bfda57bd985e56b84ca98ba5Test https://doi.org/10.3892/mmr.2019.10394Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2df898e9bfda57bd985e56b84ca98ba5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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