Expression pattern of aquaporins in patients with primary nephrotic syndrome with edema
| العنوان: | Expression pattern of aquaporins in patients with primary nephrotic syndrome with edema |
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| المؤلفون: | Kai Chen, Qing Zhang, Jihong Zhang, Yu Wang, Xiao-rong Bao, Jimei Bu |
| المصدر: | Molecular Medicine Reports |
| بيانات النشر: | Spandidos Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Nephrotic Syndrome, Urinary system, Renal function, Biology, Biochemistry, Kidney Tubules, Proximal, Pathogenesis, Edema, Genetics, medicine, Humans, Molecular Biology, Aquaporin 4, Analysis of Variance, Aquaporin 3, Kidney, Aquaporin 2, Aquaporin 1, medicine.diagnostic_test, urogenital system, Articles, Middle Aged, medicine.disease, aquaporin, medicine.anatomical_structure, Gene Expression Regulation, Oncology, Case-Control Studies, Molecular Medicine, Female, Renal biopsy, medicine.symptom, Nephrotic syndrome, Glomerular Filtration Rate |
| الوصف: | The association between the expression of aquaporins (AQPs) in kidney tissues and the occurrence of edema in nephrotic syndrome (NS) remains unclear. The current study aimed to investigate this association. A total of 54 patients with primary glomerular disease, diagnosed by renal biopsy, were divided into three groups: Control, NS without edema and NS with edema. The expression of AQP1, AQP2, AQP3 and AQP4 in kidney tissues from these patients was assessed using immunohistochemistry, and urinary AQP concentrations were quantified by ELISA. Comparison of the three groups was conducted using one way analysis of variance, independent samples t-test or the Chi-square test. AQP1 was strongly expressed in the proximal tubules. The proportion of the AQP1-positive area in kidney tissues from patients with NS with edema was significantly reduced, in comparison with the other two groups. By contrast, the proportion of the AQP2-positive area in the NS with edema group was significantly higher than that of the other two groups; significant differences were also observed between the control and NS without edema groups for this parameter. Urinary AQP2 concentrations in patients with NS (with and without edema) were significantly higher than that of the control group, and exhibited a significant positive correlation with kidney tissue AQP2 concentrations. The present study demonstrated the abnormal expression pattern of AQP1-AQP4 in the kidney tissues of patients with NS, providing a basis for an improved understanding of the role of AQP in the pathogenesis of NS. |
| تدمد: | 1791-3004 1791-2997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d20364adebd80dfa0f3472b07632367Test https://doi.org/10.3892/mmr.2015.4209Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d20364adebd80dfa0f3472b07632367 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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