دورية
Relationship of the K-ras/c-mos Expression Patterns With Angiogenesis in Non-Small Cell Lung Carcinomas
العنوان: | Relationship of the K-ras/c-mos Expression Patterns With Angiogenesis in Non-Small Cell Lung Carcinomas |
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المؤلفون: | Zacharatos, Panayotis, Kotsinas, Athanassios, Tsantoulis, Petros, Evangelou, Kostas, Kletsas, Dimitris, Asimacopoulos, Panayiotis J., Doussis-Anagnostopoulou, Ipatia, Pezzella, Francesco, Gatter, Kevin, Papavassiliou, Athanasios G., Kittas, Christos, Gorgoulis, Vassilis G. |
المصدر: | Molecular Medicine; September 2001, Vol. 7 Issue: 9 p590-597, 8p |
مستخلص: | Background: Neo-angiogenesis is an acquired capability vital for a tumor to grow and metastasize. Evidence has shown that the mitogen-activated protein (MAP) kinase pathway is involved in this process. Alterations of K-ras and c-mos, two pivotal components of this pathway, have been implicated in non-small cell lung carcinogenesis. In the present report, we examine, in a series of non-small cell lung carcinomas (NSCLCs), the status of K-ras and c-mos oncoproteins in correlation with the tumor neo-angiogenesis state and the major angiogenic factor, vascular endothelial growth factor (VEGF). Materials and Methods: c-mos and p-ERK1/2 status was evaluated immunohistochemically in a total of 65 NSCLCs, whereas the presence of K-rasmutations was examined by reverse transcriptase-polymerase chain reaction (RT-PCR) restriction fragment length polymorphism (RFLP) in available matched normal tumor material from 56 cases. Microvessel density (MVD) was estimated by immunodetection of CD |
قاعدة البيانات: | Supplemental Index |
تدمد: | 10761551 15283658 |
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DOI: | 10.1007/BF03401865 |