The biochemistry and immunology of non-canonical forms of HLA-B27
| العنوان: | The biochemistry and immunology of non-canonical forms of HLA-B27 |
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| المؤلفون: | Jacqueline Shaw, Hiroko Hatano, Simon Kollnberger |
| المصدر: | Molecular Immunology. 57(1) |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | musculoskeletal diseases, Membrane Glycoproteins, Interleukin-17, Immunology, Receptors, KIR3DL2, Immune receptor, Biology, Protein Structure, Secondary, Microvesicles, Cell biology, Immune system, LILRB2, Biochemistry, KIR3DL2, Antigen, Antigens, Surface, Humans, Spondylitis, Ankylosing, Receptors, Immunologic, skin and connective tissue diseases, Antigen-presenting cell, Receptor, Molecular Biology, HLA-B27 Antigen |
| الوصف: | HLA-B27 (B27) is strongly associated with the spondyloarthritides. B27 is expressed at the cell surface of antigen presenting cells (APC) both as canonical β2m-associated and non-canonical β2m-free heavy chain (FHC) forms which include B27 dimers (termed B272). B27 FHC forms arise in an endosomal compartment from recycling β2m-associated B27. Formation of cell surface FHC dimers is critically dependent on an unpaired reactive cysteine 67 in the α1 helix of the class I heavy chain. HLA-B27 also form redox-inducible β2m-associated dimers on exosomes and apoptosing cells. By contrast with cell surface expressed cysteine 67-dependent heavy chain dimers these dimers are dependent on a cytoplasmic cysteine 325 for their formation.HLA-B27 binds to immunoregulatory receptors including members of the Killer cell Immunoglobulin-like (KIR) and Leukocyte Immunoglobulin-like receptor family. B27 FHC bind to different but overlapping sets of these immunoreceptors compared to classical β2m-associated HLA-B27. B27 FHC bind more strongly to KIR3DL2 and LILRB2 immune receptor than other β2m-associated HLA-class I ligands. Genetic studies have implicated genes which control production of the important proinflammatory cytokine IL-17 in the pathogenesis of spondyloarthritis. Cell surface HLA-B27 FHC binding to these immune receptors or acting through other mechanisms could impact on the pathogenesis of spondyloarthritis by promoting immune cell production of IL-17. Here we review the literature on these non-canonical forms of HLA-B27 and the immune receptors they bind to and discuss the possible relevance of these interactions to the pathogenesis of spondyloarthropathy. © 2013 Elsevier Ltd. |
| اللغة: | English |
| تدمد: | 1872-9142 0161-5890 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c53959afc7047cc6b29dd9eae91741aTest http://ora.ox.ac.uk/objects/uuid:267a6540-441c-425d-8ed7-7ce12c7240a3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7c53959afc7047cc6b29dd9eae91741a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18729142 01615890 |
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