The Value of Somatostatin Receptor Imaging with In-111 Octreotide and/or Ga-68 DOTATATE in Localizing Ectopic ACTH Producing Tumors
| العنوان: | The Value of Somatostatin Receptor Imaging with In-111 Octreotide and/or Ga-68 DOTATATE in Localizing Ectopic ACTH Producing Tumors |
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| المؤلفون: | Nihat Aksakal, Cuneyt Turkmen, Berker Özkan, Işık Adalet, Yasemin Sanli, Serkan Kuyumcu, Ferihan Aral, Deniz Balköse, Ebru Yilmaz, Zeynep Gözde Özkan |
| المصدر: | Molecular Imaging and Radionuclide Therapy Molecular Imaging and Radionuclide Therapy, Vol 22, Iss 2, Pp 49-55 (2013) |
| بيانات النشر: | Galenos Publishing, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | lcsh:Medical physics. Medical radiology. Nuclear medicine, Carcinoid tumors, lcsh:R895-920, Octreotide, lcsh:Medicine, gallium radioisotopes, Scintigraphy, Cushing syndrome, indium-111-octreotide, medicine, scintigraphy, Radiology, Nuclear Medicine and imaging, positron-emission tomography/computed tomography, lcsh:R5-920, Lung, medicine.diagnostic_test, Somatostatin receptor, business.industry, Ectopic acth, lcsh:R, ectopic ACTH Syndrome, Nodule (medicine), medicine.disease, somatostatin receptor, medicine.anatomical_structure, Original Article, medicine.symptom, Nuclear medicine, business, lcsh:Medicine (General), medicine.drug |
| الوصف: | Objective: We aimed to evaluate the value of somatostatin receptor imaging (SRI) with In-111 octreotide and Ga-68 DOTATATE in localizing ectopic ACTH producing tumors. Methods: Nineteen patients who had In-111 octreotide somatostatin receptor scintigraphy (SRS) and/or Ga-68 DOTATATE PET-CT to localize ectopic ACTH producing tumors between the years 2000 and 2012 were included retrospectively in our study. The results of SRI were compared with clinical onset, radiological findings and surgical data of the patients. Results: Sixteen In-111 octreotide SRS and five Ga-68 DOTATATE PET-CT were performed in 19 patients. In eight out of 19 patients, ectopic ACTH secretion site could be detected. In five patients, SRS showed pathologic uptake. In four of these patients, surgery revealed pulmonary carcinoid tumors and in one patient pancreatic neuroendocrine tumor. In one patient, Ga-68 DOTATATE PET-CT revealed pathologic uptake in lung nodule which came out to be pulmonary carcinoid tumor. In another patient who had resection of metastases of atypical carcinoid tumor prior to scans, new metastatic foci were detected both with SRS and Ga-68 DOTATATE PET-CT imaging. In one patient, although SRS was negative, CT which was performed three years later showed a lung nodule diagnosed as pulmonary carcinoid tumor. In 11 patients, ectopic ACTH secretion site could not be detected. In 10 of those patients, scintigraphic and radiological imaging did not show any lesions and in one patient, Ga-68 DOTATATE PET-CT was false positive. Conclusion: SRI has a complementary role with radiological imaging in localizing ectopic ACTH secretion sites. PET-CT imaging with Ga-68 peptide conjugates is a promising new modality for this indication. Conflict of interest:None declared. |
| اللغة: | English |
| تدمد: | 2146-1414 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4c5522bb22852ba9821e1e24d82af8Test http://europepmc.org/articles/PMC3759309Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fe4c5522bb22852ba9821e1e24d82af8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21461414 |
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