Gene interactions observed with the HDL-c blood lipid, intakes of protein, sugar and biotin in relation to circulating homocysteine concentrations in a group of black South Africans
| العنوان: | Gene interactions observed with the HDL-c blood lipid, intakes of protein, sugar and biotin in relation to circulating homocysteine concentrations in a group of black South Africans |
|---|---|
| المؤلفون: | Jacomina P. du Plessis, Lizelle Zandberg, Cornelie Nienaber-Rousseau, Alida Melse-Boonstra |
| المساهمون: | 12257656 - Zandberg, Lizelle, 12632449 - Nienaber-Rousseau, Cornelie, 23446307 - Du Plessis, Jacomina P., 20338457 - Melse-Boonstra, Alida |
| المصدر: | Molecular Genetics and Metabolism Reports, 22 Molecular Genetics and Metabolism Reports 22 (2020) Molecular Genetics and Metabolism Reports Molecular Genetics and Metabolism Reports, Vol 22, Iss, Pp-(2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | d, Cohen's d-value, Homocysteine, RFLP, restriction fragment length polymorphism, G, guanine, Blood lipids, LDL-c, low density lipoprotein cholesterol, WT, wild type, chemistry.chemical_compound, HDL-c, high-density lipoprotein cholesterol, 0302 clinical medicine, Endocrinology, High-density lipoprotein, PCR, polymerase chain reaction, HW, Hardy Weinberg, ID, identity, THUSA, Transition and Health during Urbanization in South Africa, Methionine synthase, lcsh:QH301-705.5, Nutrigenetics, ins, insertion, 0303 health sciences, lcsh:R5-920, Blood lipid-gene interactions, %TE, percentage of total energy, biology, Nutrient-gene interactions, Gly, glycine, A, adenine, 030305 genetics & heredity, PA, physical activity, MT, mutant type, Val, valine, Gene–diet interactions, PURE, Prospective Urban and Rural Epidemiology, QFFQ, quantitative food frequency questionnaire, SNP, single-nucleotide polymorphism, lcsh:Medicine (General), MTHFR, methylenetetrahydrofolate reductase, Research Paper, GGT, gamma glutamyl transferase, medicine.medical_specialty, Hyperhomocysteinemia, CBS, cystathionine β synthase, Gene-diet interactions, Thr, threonine, Biotin, ISAK, International Society for the Advancement of Kinanthropometry, Total homocysteine, Blood lipid–gene interactions, Asp, aspartic acid, MAF, minor allele frequency, SD, standard deviations, LD, pairwise linkage-disequilibrium, MTR, methionine synthase, Ala, alanine, 03 medical and health sciences, Internal medicine, Genetics, medicine, Sugar, Molecular Biology, Ile, isoleucine, VLAG, Global Nutrition, Wereldvoeding, %TCHO, percentage total carbohydrate intake, SE, standard error, business.industry, C, cytosine, CV, coefficient variation, HWE, Hardy–Weinberg equilibrium, Protein, ES, effect size, Precision nutrition, Hcy, homocysteine, medicine.disease, HHcy, hyperhomocysteinemia, MRC, Medical Research Council, Cystathionine beta synthase, GLM, generalized linear model, Minor allele frequency, bp, base pairs, chemistry, lcsh:Biology (General), CI, confidence intervals, SFA, saturated fatty acids, Nutrient–gene interactions, Methylenetetrahydrofolate reductase, biology.protein, HbA1c, glycated hemoglobin, business, T, thymine, 030217 neurology & neurosurgery |
| الوصف: | Background: Elevated homocysteine (Hcy) is associated with several pathologies. Gene–diet interactions related to Hcy might be used to customize dietary advice to reduce disease incidence. To explore this possibility, we investigated interactions between anthropometry, biochemical markers and diet and single-nucleotide polymorphisms (SNPs) in relation to Hcy concentrations. Five SNPs of Hcy-metabolizing enzymes were analyzed in 2010 black South Africans. Results: Hcy was higher with each additional methylenetetrahydrofolate reductase (MTHFR) C677T minor allele copy, but was lower in methionine synthase (MTR) 2756AA homozygotes than heterozygotes. Individuals harboring cystathionine β synthase (CBS) 833 T/844ins68 had lower Hcy concentrations than others. No interactive effects were observed with any of the anthropometrical markers. MTHFR C677T and CBS T833C/844ins68 homozygote minor allele carriers presented with lower Hcy as high density lipoprotein cholesterol (HDL-c) increased. Hcy concentrations were negatively associated with dietary protein and animal protein intake in the TT and TC genotypes, but positively in the CC genotype of CBS T833C/844ins68. Hcy was markedly higher in TT homozygotes of MTHFR C677T as added sugar intake increased. In CBS T833C/844ins68 major allele carriers, biotin intake was negatively associated with Hcy; but positively in those harboring the homozygous minor allele. Conclusions: The Hcy–SNP associations are modulated by diet and open up the possibility of invoking dietary interventions to treat hyperhomocysteinemia. Future intervention trials should further explore the observed gene–diet and gene–blood lipid interactions. Keywords: Biotin, Blood lipid–gene interactions, Gene–diet interactions, Hyperhomocysteinemia, Nutrient–gene interactions, Nutrigenetics, Precision nutrition, Protein, Sugar, Total homocysteine |
| وصف الملف: | application/octet-stream; application/pdf |
| اللغة: | English |
| تدمد: | 2214-4269 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e094a32b1cc86c261c27a4bc390a2c80Test https://doi.org/10.1016/j.ymgmr.2019.100556Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e094a32b1cc86c261c27a4bc390a2c80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22144269 |
|---|