Enteral tube feeding in patients receiving dietary treatment for metabolic diseases: A retrospective analysis in a large French cohort
| العنوان: | Enteral tube feeding in patients receiving dietary treatment for metabolic diseases: A retrospective analysis in a large French cohort |
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| المؤلفون: | Célina Roda, Pascale de Lonlay pascale, Clément Pontoizeau, Pierre-Jean Bérat, Pauline Gaignard, Guy Touati, Elise Lebigot, Jean-Baptiste Arnoux, M. Assoun, Valérie Barbier, Sandrine Dubois, Camille Wicker, Cécile Talbotec, Claire Belloche, Virginie Leboeuf, Anaïs Brassier, Aude Servais, Juliette Bouchereau, Chris Ottolenghi, Francois Michael Petit, F. Campeotto, Claire-Marine Bérat |
| المصدر: | Molecular Genetics and Metabolism Reports Molecular Genetics and Metabolism Reports, Vol 26, Iss, Pp 100655-(2021) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, medicine.medical_treatment, Context (language use), Disease, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, food, Genetics, medicine, In patient, Molecular Biology, lcsh:QH301-705.5, Enteral Tube Feeding, 0303 health sciences, lcsh:R5-920, Maple syrup, business.industry, 030305 genetics & heredity, Dietary management, Gastrostomy, food.food, lcsh:Biology (General), Cohort, business, lcsh:Medicine (General), 030217 neurology & neurosurgery, Research Paper |
| الوصف: | Context A strictly controlled diet (often involving enteral tube feeding (ETF)) is part of the treatment of many inherited metabolic diseases (IMDs). Objective To describe the use of ETF in a large cohort of patients with IMDs. Design A retrospective analysis of ETF in patients with urea cycle disorders (UCDs), organic aciduria (OA), maple syrup disease (MSUD), glycogen storage diseases (GSDs) or fatty acid oxidation disorders (FAODs) diagnosed before the age of 12 months. Setting The reference center for IMDs at Necker Hospital (Paris, France). Results 190 patients born between January 1991 and August 2017 were being treated for OA (n = 60), UCDs (n = 55), MSUD (n = 32), GSDs (n = 26) or FAODs (n = 17). Ninety-eight of these patients (52%) received ETF (OA subgroup: n = 40 (67%); UCDs: n = 12 (22%); MSUD: n = 9 (28%); GSDs: n = 23 (88%); FAODs: n = 14 (82%)). Indications for ETF were feeding difficulties in 64 (65%) patients, cessation of fasting in 39 (40%), and recurrent metabolic decompensation in 14 (14%). Complications of ETF were recorded in 48% of cases, more frequently with nasogastric tube (NGT) than with gastrostomy. Among patients in whom ETF was withdrawn, the mean duration of ETF was 5.9 (SD: 4.8) years (range: 0.6–19.8 years). The duration of ETF was found to vary from one disease subgroup to another (p = 0.051). While the longest median duration was found in the GSD subgroup (6.8 years), the shortest one was found in the UCD subgroup (0.9 years). Conclusion ETF is an integral part of the dietary management of IMDs. The long duration of ETF and the specific risks of NGT highlights the potential value of gastrostomy. In this study at a French tertiary hospital, we documented the indications, modalities, duration and complications of enteral tube feeding in a cohort of patients with inherited metabolic diseases. |
| تدمد: | 2214-4269 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc665b996ce23377d350d48ae146c71Test https://pubmed.ncbi.nlm.nih.gov/33473351Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bdc665b996ce23377d350d48ae146c71 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22144269 |
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