Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma
| العنوان: | Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma |
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| المؤلفون: | Marie-Magdeleine Ruchoux, Jacqueline Mikol, Isabelle Salmon, Dominique Figarella-Branger, David W. Ellison, Emmanuel Rousseau, Francesco Scaravilli, Catherine Lacroix, Thomas Palm, Catherine Godfraind, Miikka Vikkula, Françoise Chapon |
| المساهمون: | UCL - MD/MNOP - Département de morphologie normale et pathologique, UCL - MD/BICL - Département de biochimie et de biologie cellulaire, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Centre de génétique médicale UCL, UCL - (SLuc) Centre de malformations vasculaires congénitales |
| المصدر: | Molecular Cancer, Vol 6, Iss 1, p 47 (2007) Molecular Cancer, Vol. 6, p. 47 [1-10] (2007) Molecular Cancer Molecular cancer, 6 |
| بيانات النشر: | BMC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Ependymoma, Chromosomes, Human, Pair 11 -- genetics, Microsatellite Repeats -- genetics, Male, Pathology, Cancer Research, Tissue Fixation, Trisomy, medicine.disease_cause, Chromosomes, Human, Pair 19 -- genetics, Child, Glial fibrillary acidic protein, biology, Brain Neoplasms, Nucleic Acid Hybridization, Sciences bio-médicales et agricoles, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Oncology, Child, Preschool, Molecular Medicine, Female, Chromosome Deletion, Ependymoma -- pathology, Chromosomes, Human, Pair 9, Adult, medicine.medical_specialty, Adolescent, Chromosome 9, Brain Neoplasms -- genetics, Polymorphism, Single Nucleotide, lcsh:RC254-282, Brain Neoplasms -- pathology, Chromosome 19, medicine, Humans, Tissue Array Analysis -- methods, Ependymoma -- genetics, Aged, Genome, Human, Research, Chromosomes, Human, Pair 11, Infant, Tissue Fixation -- methods, medicine.disease, Nucleic Acid Hybridization -- methods, Tissue Array Analysis, biology.protein, Human genome, Carcinogenesis, Chromosomes, Human, Pair 9 -- genetics, Chromosomes, Human, Pair 19, Clear cell, Microsatellite Repeats |
| الوصف: | Ependymal tumors constitute a clinicopathologically heterogeneous group of brain tumors. They vary in regard to their age at first symptom, localization, morphology and prognosis. Genetic data also suggests heterogeneity. We define a newly recognized subset of ependymal tumors, the trisomy 19 ependymoma. Histologically, they are compact lesions characterized by a rich branched capillary network amongst which tumoral cells are regularly distributed. When containing clear cells they are called clear cell ependymoma. Most trisomy 19 ependymomas are supratentorial WHO grade III tumors of the young. Genetically, they are associated with trisomy 19, and frequently with a deletion of 13q21.31-31.2, three copies of 11q13.3-13.4, and/or deletions on chromosome 9. These altered chromosomal regions are indicative of genes and pathways involved in trisomy 19 ependymoma tumorigenesis. Recognition of this genetico-histological entity allows better understanding and dissection of ependymal tumors. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| تدمد: | 1476-4598 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af54cbe2d2dac6f2f69f1a8c767f0baTest http://www.molecular-cancer.com/content/6/1/47Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0af54cbe2d2dac6f2f69f1a8c767f0ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764598 |
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