Sterol regulatory element-binding transcription factor (SREBF)-2, SREBF cleavage-activating protein (SCAP), and premature coronary artery disease in a Chinese population
| العنوان: | Sterol regulatory element-binding transcription factor (SREBF)-2, SREBF cleavage-activating protein (SCAP), and premature coronary artery disease in a Chinese population |
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| المؤلفون: | Qi Qian, Genshan Ma, Zhong Chen, Zhen Ding, Naifeng Liu |
| المصدر: | Molecular Biology Reports. 38:2895-2901 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Myocardial Infarction, Single-nucleotide polymorphism, Coronary Artery Disease, Biology, Coronary Angiography, Cleavage (embryo), Polymorphism, Single Nucleotide, Sudden cardiac death, Asian People, Risk Factors, Internal medicine, Genetics, medicine, Humans, SNP, Genetic Predisposition to Disease, Myocardial infarction, Molecular Biology, Transcription factor, Intracellular Signaling Peptides and Proteins, Membrane Proteins, General Medicine, Middle Aged, medicine.disease, Sterol, Cholesterol, Death, Sudden, Cardiac, Endocrinology, Female, Homeostasis, Sterol Regulatory Element Binding Protein 2 |
| الوصف: | Cellular cholesterol homeostasis is controlled by the sterol-regulatory element binding transcription factors (SREBFs) that are activated by an SREBF cleavage-activating protein (SCAP). SREBF-2 1784GC single nucleotide polymorphism (SNP, rs2228314) and SCAP 2386AG variant (rs12487736) are associated with early onset myocardial infarction (MI) and sudden cardiac death in middle-aged men. We investigated whether these two SNPs are determinants of premature coronary artery disease (CAD) in a Chinese population. We studied 431 consecutive patients, including 197 with coronary stenosis ≥50% or previous MI and 234 controls without documented CAD (males55 years and females65 years). All subjects were genotyped for two SNPs by using the ligase detection reaction method. The three genotypes GG, GC, and CC were present in rs2228314 and two genotypes AA and AG in rs12487736. No gender-specific differences were found in genotype distribution and allele frequencies of these two SNPs between patients with and without CAD. The biochemical and clinical risk factors among participants were not influenced by variants at rs2228314. Logistic regression did not detect the association of these two SNPs with premature CAD, nor did there exist any association of these two SNPs among groups of patients with 0, 1, 2, and 3-vessel disease (all P0.05). We could not identify any association between these two SNPs and premature CAD or extent of coronary lesions in a Chinese population. |
| تدمد: | 1573-4978 0301-4851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9224a83e3268fd911ae00107756b53bTest https://doi.org/10.1007/s11033-010-9951-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a9224a83e3268fd911ae00107756b53b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
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