A novel major histocompatibility complex locus confers the risk of premature coronary artery disease in a Chinese Han population
| العنوان: | A novel major histocompatibility complex locus confers the risk of premature coronary artery disease in a Chinese Han population |
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| المؤلفون: | Fangyi Xie, Zhong Chen, Genshan Ma, Zhen Ding |
| المصدر: | Molecular Biology Reports. 40:3649-3654 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Risk, China, medicine.medical_specialty, Genotype, Single-nucleotide polymorphism, Comorbidity, Coronary Artery Disease, Disease, Major Histocompatibility Complex, Coronary artery disease, Asian People, Internal medicine, Genetics, medicine, Humans, Genetic Predisposition to Disease, Myocardial infarction, Molecular Biology, Alleles, Genetic association, business.industry, Case-control study, General Medicine, Odds ratio, Middle Aged, medicine.disease, Case-Control Studies, Cardiology, Female, business |
| الوصف: | Several novel loci have been proved to be associated with coronary artery disease and/or myocardial infarction risk by genome-wide association studies, however, the available coronary artery disease risk variants explain only a small proportion of the predicted genetic heritability of the disease. Recently, a novel coronary artery disease locus on chromosome 6p21.3 in the major histocompatibility complex was identified in an European population. We hereby investigated whether this single nucleotide polymorphisms (rs3869109) confers the risk of premature coronary artery disease in a Chinese Han population. A total of 422 patients were studied including 210 cases with coronary stenosis ≥50% or previous myocardial infarction (male55 years and female65 years) and 212 controls without documented coronary artery disease. Ligase detection reaction was performed to detect rs3869109. The 3 genotypes AA, AG, and GG were present in rs3869109. There were significant differences between the control and premature coronary artery disease groups in the frequencies of the rs3869109 variants and alleles (all P0.05). The distribution of 3 genotypes and alleles at rs3869109 does not differ between women and men (all P0.05). There was a significant association between rs3869109 genotypes and the severity of premature coronary artery disease (P = 0.038). Multivariate logistic regression showed that carriers with AG and GG genotypes at rs3869109 have a higher risk of premature coronary artery disease than carriers of AA genotype (odds ratio [OR] 1.997, 95% CI: 1.166-3.419, P = 0.012; OR 1.695, 95% CI: 1.044-2.752, P = 0.033; respectively). Our results indicate that the rs3869109 variants are associated with premature coronary artery disease in a Chinese Han population, suggesting this genetic risk marker is useful in early coronary artery disease risk prediction. |
| تدمد: | 1573-4978 0301-4851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a5a9e82b5d7f42a361732771c86d0eTest https://doi.org/10.1007/s11033-012-2440-zTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a5a5a9e82b5d7f42a361732771c86d0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
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