Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population
| العنوان: | Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population |
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| المؤلفون: | Qi Qian, Yuyu Yao, Genshan Ma, Xiaofeng Zhang, Zhong Chen |
| المصدر: | Molecular Biology Reports. 37:207-212 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, China, medicine.medical_specialty, endocrine system diseases, Single-nucleotide polymorphism, Coronary Artery Disease, Type 2 diabetes, Polymorphism, Single Nucleotide, Asian People, Gene Frequency, Diabetes mellitus, Internal medicine, Genotype, Genetics, medicine, Humans, Genetic Predisposition to Disease, Myocardial infarction, Age of Onset, Allele, Molecular Biology, business.industry, Type 2 Diabetes Mellitus, General Medicine, Middle Aged, medicine.disease, Stenosis, Diabetes Mellitus, Type 2, Case-Control Studies, KCNQ1 Potassium Channel, Female, business |
| الوصف: | Four single nucleotide polymorphisms (SNPs, rs2237892, rs2237895, rs2237897, rs2283228) in KCNQ1 are associated with type 2 diabetes mellitus in different ancestral groups. We investigated whether these 4 genetic markers are determinants of type 2 diabetes and premature coronary artery disease (CAD) in a Chinese population. We studied 398 consecutive patients, including 180 with coronary stenosisor=50% or previous myocardial infarction (male55 years, female65 years) and 218 controls without documented CAD. CAD cases and controls were genotyped for 4 SNPs by using the ligase detection reaction method. The 3 genotypes AA, AC, and CC were present in rs2283228 and rs2237895, and the 3 genotypes CC, CT, TT were present in rs2237897 and rs2237892. No differences were found in genotype distribution and allele frequencies of these 4 SNPs between subjects with and without type 2 diabetes. Logistic regression showed that the risk of premature CAD in subjects carrying the CC genotype at rs2237892 was reduced by 90% in relation to individuals carrying the TT genotype (OR = 0.100, 95% CI: 0.018-0.564, P = 0.009). The association of other 3 SNPs with premature CAD could not be detected, nor did there exist any association of these 4 SNPs among groups of patients with 0, 1, 2, and 3-vessel disease (all P0.05). Our data implicate rs2237892 in KCNQ1 as a protective gene variant against premature CAD and we couldn't replicate any association of these 4 SNPs with T2DM or extent of coronary lesions in a Chinese population. |
| تدمد: | 1573-4978 0301-4851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4113147579e11fc47d824993807cc187Test https://doi.org/10.1007/s11033-009-9597-0Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4113147579e11fc47d824993807cc187 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
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