IL-1ra anti-inflammatory cytokine polymorphism is associated with risk of gastric cancer and chronic gastritis in a Brazilian population, but the TNF-β pro-inflammatory cytokine is not
| العنوان: | IL-1ra anti-inflammatory cytokine polymorphism is associated with risk of gastric cancer and chronic gastritis in a Brazilian population, but the TNF-β pro-inflammatory cytokine is not |
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| المؤلفون: | M. Cristina Duarte, J. Garcia Oliveira, A. Elizabete Silva |
| المصدر: | Molecular Biology Reports. 39:7617-7625 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Genotype, Population, Chronic gastritis, Polymorphism, Single Nucleotide, Helicobacter Infections, Proinflammatory cytokine, Young Adult, Stomach Neoplasms, Genetics, medicine, Humans, Genetic Predisposition to Disease, Allele, education, Lymphotoxin-alpha, Molecular Biology, Alleles, Aged, Aged, 80 and over, education.field_of_study, Helicobacter pylori, biology, Case-control study, Genetic Variation, Receptors, Interleukin-1, General Medicine, Middle Aged, biology.organism_classification, medicine.disease, Genotype frequency, Interleukin 1 Receptor Antagonist Protein, Case-Control Studies, Gastritis, Immunology, Female, Brazil |
| الوصف: | Genetic polymorphisms in genes that codify inflammatory cytokines have been associated with gastric carcinogenesis. This study evaluated polymorphisms IL-1RN VNTR and TNFB+252A/G in a population from Southeast Brazil with regard to the risk of chronic gastritis and gastric cancer and the presence of an association of gastric lesions with risk factors such as gender, age, smoking, drinking and Helicobacter pylori infection. In this case-control study, polymorphism at IL-1RN VNTR was investigated using the allele-specific polymerase chain reaction method, while the polymerase chain reaction-restriction fragment length polymorphism technique was used to identify the TNFB+252A/G genotype in 675 Brazilian individuals [229 with chronic gastritis (CG), 200 with gastric cancer (GC) and 246 healthy individuals as controls (C)]. Multiple logistic regression analysis (log-additive, dominant, and recessive models) have not showed association of the genotype frequencies for the SNP TNFB + 252A/G with risk of CG or GC. However, as for IL-1RN VNTR it was observed significant differences in all three analysis models, with higher values of OR in recessive model, both in the GC group (OR = 3.04, 95% CI = 1.41-6.56, p < 0.01) and CG (OR = 2.32, 95% CI = 1.10-4.90, p = 0.02) compared to the C group. In addition, the multiple logistic regression showed also an association with risk factors such as male gender, older age and alcohol intake regarded GC group. So, our results indicated that the IL-1RN*2 allele may increase the risk of gastric cancer and precancerous lesions in the Southeast Brazilian population, reinforcing the importance of host genetic factors in the susceptibility to gastric cancer and the participation of cytokines in both the inflammation and the carcinogenic process. |
| تدمد: | 1573-4978 0301-4851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ed2023e6803bae7dfa898ffda56002Test https://doi.org/10.1007/s11033-012-1596-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....12ed2023e6803bae7dfa898ffda56002 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
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