دورية
Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons
| العنوان: | Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons |
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| المؤلفون: | van Gelder, Charlotte A. G.H., Penning, Renske, Veth, Tim S., Catsburg, Lisa A.E., Hoogenraad, Casper C., MacGillavry, Harold D., Altelaar, Maarten |
| المصدر: | Molecular and Cellular Proteomics (MCP Online); December 2020, Vol. 19 Issue: 12 p1952-1968, 17p |
| مستخلص: | We integrated quantitative phosphoproteomics with the analyses of newly synthesized proteins in a pulsed labeling strategy in cultured hippocampal neurons stimulated with DHPG to study mGluR-induced signaling pathways. We identified and validated several kinases involved in mGluR activation, and constructed an overview of protein phosphorylation and synthesis, validating Intersectin-1 as a novel player in AMPA receptor endocytosis. This study revealed several new insights, and provides a rich resource into the molecular pathways downstream of group I mGluR activation. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 15359476 15359484 |
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| DOI: | 10.1074/mcp.RA120.002199 |