T(14;18)(q32;q21) involving MALT1 and IGH genes occurs in extranodal diffuse large B-cell lymphomas of the breast and testis
| العنوان: | T(14;18)(q32;q21) involving MALT1 and IGH genes occurs in extranodal diffuse large B-cell lymphomas of the breast and testis |
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| المؤلفون: | J. Han van Krieken, Max I. Schreuder, Anita H. Gemmink, Marion J J Kuper-Hommel |
| المصدر: | Modern Pathology, 26, 421-7 Modern Pathology, 26, 3, pp. 421-7 |
| بيانات النشر: | Elsevier BV, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Genes, Immunoglobulin Heavy Chain, Breast Neoplasms, Trisomy, Biology, Translocation, Genetic, Pathology and Forensic Medicine, Chromosome Breakpoints, Testicular Neoplasms, immune system diseases, hemic and lymphatic diseases, medicine, Chromosomes, Human, Humans, Registries, Thyroid Neoplasms, In Situ Hybridization, Fluorescence, B cell, Aged, Aged, 80 and over, Chromosome Aberrations, medicine.diagnostic_test, Thyroid, Middle Aged, Prognosis, medicine.disease, Marginal zone, Translational research Tissue engineering and pathology [ONCOL 3], Neoplasm Proteins, Lymphoma, MALT1, medicine.anatomical_structure, Chromosome 3, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein, Caspases, Female, Lymphoma, Large B-Cell, Diffuse, Fluorescence in situ hybridization |
| الوصف: | Contains fulltext : 117721.pdf (Publisher’s version ) (Closed access) Primary B-cell lymphoma of the testis, breast and thyroid are rare and data concerning cytogenetic aberrations at these extranodal sites are scarce. We examined the presence of extranodal marginal zone lymphoma-associated translocations, t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21), t(3;14)(p14.1;q32) and numerical aberrations of chromosomes 1, 3, 12 and 18 by fluorescence in situ hybridization in 6 extranodal marginal zone lymphomas and 24 diffuse large B-cell lymphomas with (n=9) or without (n=15) marginal zone lymphoma components, with primary localizations in the breast (n=15), testis (n=9) and thyroid (n=6). We found t(14;18)(q32;q21), with breakpoints in IGH and MALT1, in one testicular diffuse large B-cell lymphoma and in two diffuse large B-cell lymphomas of the breast. No other translocations, amplifications or deletions involving IGH, BCL-10, BCL-2, MALT1 and IAP2 were detected. Numerical aberrations occurred in 67% of the lymphomas, 67% of extranodal marginal zone lymphomas, 56% of diffuse large B-cell lymphomas with marginal zone lymphoma components and in 73% of 'de novo' diffuse large B-cell lymphomas. These included 78% of testis, 67% of thyroid and 60% of breast lymphomas, and included mainly trisomy 18 (n=16), trisomy 3 (n=8) and trisomy 1 (n=3). One testicular diffuse large B-cell lymphoma harbored both t(14;18)(q32;q21) and trisomy 3. Our results indicate that at least a few cases of diffuse large B-cell lymphoma of the testis and the breast belong to the spectrum of extranodal marginal zone lymphoma. |
| وصف الملف: | application/pdf |
| تدمد: | 0893-3952 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7b880b1a36152d2f2c805ca05df709Test https://doi.org/10.1038/modpathol.2012.170Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dc7b880b1a36152d2f2c805ca05df709 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08933952 |
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