Intraneural synovial sarcoma: two cases
| العنوان: | Intraneural synovial sarcoma: two cases |
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| المؤلفون: | Jean Benhattar, Peiguo G. Chu, Kathleen Meagher-Villemure, Lawrence M. Weiss |
| المصدر: | Modern Pathology. |
| بيانات النشر: | Elsevier BV, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Nerve root, Oncogene Proteins, Fusion, Malignant peripheral nerve sheath tumor, Schwannoma, Nerve Sheath Neoplasms, Translocation, Genetic, Pathology and Forensic Medicine, Diagnosis, Differential, Sarcoma, Synovial, Peripheral Nervous System Neoplasms, medicine, Humans, Child, business.industry, Reverse Transcriptase Polymerase Chain Reaction, Nodule (medicine), Anatomy, Middle Aged, medicine.disease, Immunohistochemistry, Synovial sarcoma, Microscopy, Electron, Female, Sarcoma, medicine.symptom, business, Neurilemmoma |
| الوصف: | We report two cases of intraneural synovial sarcoma. The first patient is a 46-year-old female who presented for several months with soft-tissue mass in the right infra-auricular region. The second patient is a 11-year-old girl who fell and then presented with pain in the area innervated by the right C7 spinal root and a nodule identified in the nerve root foramina. Both lesions were of small size and presented with features of synovial sarcoma. A biphasic variant was found in case 1 and a monophasic variant was present in case 2. Immunohistochemical studies were performed to confirm the diagnosis, excluding the main differential diagnoses, namely schwannoma and malignant peripheral nerve sheath tumor. Ultrastructural study was performed in case 2 allowing exclusion of other possible diagnoses. Molecular studies were performed on paraffin-embedded tissue in both cases and revealed the known characteristic t(X;18)(SYT-SSX) translocation. |
| تدمد: | 1530-0285 0893-3952 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6a6fa779a5d44fc59bc852e78a66d4Test https://doi.org/10.1038/sj.modpathol.3800048Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....db6a6fa779a5d44fc59bc852e78a66d4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15300285 08933952 |
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