Risk Factors and Outcome of Multidrug-Resistant Infections after Heart Transplant: A Contemporary Single Center Experience
| العنوان: | Risk Factors and Outcome of Multidrug-Resistant Infections after Heart Transplant: A Contemporary Single Center Experience |
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| المؤلفون: | Irene Mattucci, Roberto Andini, Emanuele Durante-Mangoni, Raffaele Zarrilli, Mariano Bernardo, Cristiano Amarelli, Domenico Iossa, Arta Karruli, Rosa Zampino, Jacopo de Cristofaro |
| المساهمون: | Karruli, A., de Cristofaro, J., Andini, R., Iossa, D., Bernardo, M., Amarelli, C., Mattucci, I., Zampino, R., Zarrilli, R., Durante-Mangoni, E. |
| المصدر: | Microorganisms, Vol 9, Iss 1210, p 1210 (2021) Microorganisms Volume 9 Issue 6 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Klebsiella pneumoniae, QH301-705.5, 030106 microbiology, Single Center, Microbiology, Article, 03 medical and health sciences, 0302 clinical medicine, Virology, Internal medicine, Antibiotic therapy, Surgical site, MDR, medicine, Retrospective analysis, XDR, risk factors, 030212 general & internal medicine, Biology (General), heart transplant, Outcome, biology, business.industry, biology.organism_classification, infection, Multiple drug resistance, Risk factor, Outcome data, business, Hospital stay, hospitalization |
| الوصف: | (1) Background: The aim of this study was to assess risk factors for multidrug-resistant/extensively drug-resistant (MDR/XDR) bacterial infections in heart transplant (HT) patients within three months after surgery and its impact on patient outcome. (2) Methods: Retrospective analysis of clinical, hemato-chemical, imaging, treatment and outcome data from 47 heart transplant recipients from January 2016 to December 2018. MDR/XDR infections were compared to non-MDR/XDR and noninfected patients. (3) Results: Most participants were males, median age 51 years: 35 (74.5%) developed an infection after HT 14 (29.8%) were MDR/XDR infections. Prolonged hospital stay before HT correlated to MDR/XDR infection (p < 0.001). Sequential organ failure assessment (SOFA) score at sampling day was higher in MDR/XDR (p = 0.027). MDR/XDR were mostly blood-stream (BSI) (p = 0.043) and skin-soft tissue (SSTI) (p = 0.047) infections. Gram-negative infections were the most frequent, specifically carbapenem-resistant Klebsiella pneumoniae. Antibiotic therapy duration for MDR/XDR infections was longer (p = 0.057), eradication rate lower (p = 0.083) and hospital stay longer (p = 0.005) but not associated with a worse outcome. (4) Conclusions: MDR/XDR infections affect compromised HT recipients with a history of prolonged hospitalization, causing a lower rate of eradication and increased hospital stay. These frequently present as BSI and SSTI. We emphasize the need to prevent contamination of central venous catheters and the surgical site. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-2607 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ec3cd1b85c982a38f341f5092ed487Test https://www.mdpi.com/2076-2607/9/6/1210Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....24ec3cd1b85c982a38f341f5092ed487 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20762607 |
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