The Proteome of Community Living Candida albicans Is Differentially Modulated by the Morphologic and Structural Features of the Bacterial Cohabitants
| العنوان: | The Proteome of Community Living Candida albicans Is Differentially Modulated by the Morphologic and Structural Features of the Bacterial Cohabitants |
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| المؤلفون: | Li Mei Pang, Sarah Sze Wah Wong, Chaminda Jayampath Seneviratne, Yi Man Eva Fung, Lakshman P. Samaranayake, Thuyen Truong, Suhasini Rajan |
| المصدر: | Microorganisms Volume 8 Issue 10 Microorganisms, Vol 8, Iss 1541, p 1541 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Microbiology (medical), Microbiology, polymicrobial interkingdom biofilms, Streptococcus sobrinus, Article, 03 medical and health sciences, Virology, Streptococcus mitis, Ligase activity, limma differential expression analysis, Candida albicans, lcsh:QH301-705.5, 030304 developmental biology, 0303 health sciences, biology, 030302 biochemistry & molecular biology, gene ontology analysis, biology.organism_classification, Corpus albicans, Streptococcus sanguinis, stomatognathic diseases, lcsh:Biology (General), label free mass spectrometry analysis, Actinomyces naeslundii, Fusobacterium nucleatum, cluster analysis |
| الوصف: | Candida albicans is a commensal polymorphic and opportunistic fungus, which usually resides as a small community in the oral cavities of a majority of humans. The latter eco-system presents this yeast varied opportunities for mutualistic interactions with other cohabitant oral bacteria, that synergizes its persistence and pathogenicity. Collectively, these communities live within complex plaque biofilms which may adversely affect the oral health and increase the proclivity for oral candidiasis. The proteome of such oral biofilms with myriad interkingdom interactions are largely underexplored. Herein, we employed limma differential expression analysis, and cluster analysis to explore the proteomic interactions of C. albicans biofilms with nine different common oral bacterial species, Aggregatibacter actinomycetemcomitans, Actinomyces naeslundii, Fusobacterium nucleatum, Enterococcus faecalis, Porphyromonas gingivalis, Streptococcus mutants, Streptococcus sanguinis, Streptococcus mitis, and Streptococcus sobrinus. Interestingly, upon exposure of C. albicans biofilms to the foregoing heat-killed bacteria, the proteomes of the fungus associated with cellular respiration, translation, oxidoreductase activity, and ligase activity were significantly altered. Subsequent differential expression and cluster analysis revealed the subtle, yet significant alterations in the C. albicans proteome, particularly on exposure to bacteria with dissimilar cell morphologies, and Gram staining characteristics. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-2607 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1785c5e7007806e849048952e9894758Test http://europepmc.org/articles/PMC7601143Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1785c5e7007806e849048952e9894758 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20762607 |
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